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Lactated Ringer
Lactated Ringer is a crystalloid intravenous fluid that replaces lost fluids and electrolytes to restore intravascular volume and maintain physiological balance.
Lactated Ringer is a crystalloid intravenous fluid that replaces lost fluids and electrolytes to restore intravascular volume and maintain physiological balance. Used for Hypovolemia and dehydration, Acute blood loss and hemorrhagic shock, Perioperative fluid maintenance and resuscitation.
At a glance
| Generic name | Lactated Ringer |
|---|---|
| Also known as | Solution, Aggressive fluid resuscitation, Moderate fluid resuscitation, Restrictive fluid resuscitation, COMPOUND SODIUM LACTATE INJECTION I.P., INVEN PHARMACEUTICALS PVT.LTD, MP, INDIA |
| Sponsor | Fayoum University Hospital |
| Drug class | Crystalloid intravenous fluid |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Fluid Resuscitation |
| Phase | FDA-approved |
Mechanism of action
Lactated Ringer solution contains sodium, potassium, calcium, chloride, and lactate in concentrations approximating plasma. It restores circulating volume in dehydration, hemorrhage, or shock states, and the lactate is metabolized by the liver to bicarbonate, providing mild alkalinizing effects. It is used for fluid resuscitation and maintenance therapy in various clinical settings.
Approved indications
- Hypovolemia and dehydration
- Acute blood loss and hemorrhagic shock
- Perioperative fluid maintenance and resuscitation
- Burn management
Common side effects
- Hyperkalemia
- Fluid overload / pulmonary edema
- Hyperchloremic acidosis
- Phlebitis at infusion site
Key clinical trials
- Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease (GVHD) Unresponsive to Conventional Treatments (PHASE2)
- Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery (PHASE1)
- Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy (PHASE2)
- Evaluation of Intravenous Sodium Valproate on Interleukin-6 Levels in Patients With TMJ Disc Displacement (PHASE2)
- Precision Resuscitation With Crystalloids in Sepsis (NA)
- A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial) (PHASE2)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Volume Kinetics of Fluid Resuscitation in Early Sepsis
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |