NCT03215680 (LION) is a clinical trial of Climate in Iodine Deficiency, sponsored by Swiss Federal Institute of Technology.

Who is sponsoring NCT03215680?

NCT03215680 is sponsored by Swiss Federal Institute of Technology.

What drugs are being tested in NCT03215680?

Interventions in NCT03215680: Climate.

What condition does NCT03215680 study?

NCT03215680 studies Iodine Deficiency.

Is NCT03215680 still recruiting?

NCT03215680 is currently completed. Last updated 26 March 2021.

Last reviewed 2021-03-26 · How we verify

NCT03215680: LION

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Climat Impact on Urinary Iodine Concentration

Completed Last updated 26 March 2021

What this trial tests

trial testing Climate in Iodine Deficiency in 363 participants. Completed in 31 December 2018.

Timeline

10 July 2017

Primary endpoint
31 December 2018

31 December 2018

Quick facts

Lead sponsor	Swiss Federal Institute of Technology
Status	Completed
Study type	OBSERVATIONAL
Enrollment	363
Start date	10 July 2017
Primary completion	31 December 2018
Estimated completion	31 December 2018
Sites	2 locations across South Africa, Tanzania

Drugs / interventions tested

Climate

Conditions studied

Iodine Deficiency — all drugs for Iodine Deficiency →

Sponsor

Swiss Federal Institute of Technology

Who can join

Adults 18 to 49, female only, with Iodine Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Urinary iodine concentration (UIC) is the recommended biomarker of iodine status in populations. Yet, the influence of climate on UIC remains unclear. Hot climate may reduce urine volume and consequently increase UIC independent of iodine status. This could lead to an overestimation of population iodine intake, thus masking iodine deficiency in vulnerable groups. In this longitudinal observational cohort study in women of reproductive age we will collect 24h and spot urine samples in the summer and winter season. The influence of high temperature climates on UIC, measured and estimated urinary iodine excretion will be estimated.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Seasonal effects on urinary iodine concentrations in women of reproductive age: An observational study in Tanzania and South Africa.
Arns-Glaser L, Zandberg L, Assey VD, Baumgartner J, et al · · 2022 · cited 3× · PMID 34601579 · DOI 10.1093/ajcn/nqab327

Verify or expand the search:

Other recruiting trials for Iodine Deficiency

Currently open trials in the same condition.

NCT06801691 — The Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe · NA · recruiting
NCT06769009 — EUthyroid2: the Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europ · NA · recruiting
NCT06775795 — The Bioavailability of Iodine in Plant-based Milk Alternatives · NA · active not recruiting
NCT04288531 — Iodine Impact on Thyroid Function and Psychomotor Development, Observational Study in the Portuguese Minho Region · active not recruiting

Other Swiss Federal Institute of Technology trials

Trials by the same sponsor.

NCT07182734 — Feasibility of Unsupervised Therapy After Neurological or Orthopaedical Injury in the Home Setting With a Hand Rehabilit · NA · not yet recruiting
NCT06725784 — Feasibility and Cost of Robot-assisted Upper Limb Rehabilitation with Different Levels of Supervision · NA · recruiting
NCT06851130 — Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women · NA · recruiting
NCT06149975 — Feasibility of a Motor-cognitive Training Program in Patients With Traumatic Brain Injury · NA · completed
NCT06116669 — Effects of Oral Iron Supplementation Before vs at Time of Vaccination on Immune Response in Iron Deficient Kenyan Women · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03215680 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Swiss Federal Institute of Technology
Last refreshed: 26 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03215680.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing