NCT03212482 is a clinical trial in Brain Injuries, sponsored by Jian-Xin Zhou.

Who is sponsoring NCT03212482?

NCT03212482 is sponsored by Jian-Xin Zhou.

What condition does NCT03212482 study?

NCT03212482 studies Brain Injuries, Mechanical Ventilation.

Is NCT03212482 still recruiting?

NCT03212482 is currently completed. Last updated 29 May 2020.

Last reviewed 2020-05-29 · How we verify

NCT03212482

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Patient-ventilator Asynchrony in Patients With Brain Injury

Completed Last updated 29 May 2020

What this trial tests

trial in Brain Injuries in 100 participants. Completed in 29 February 2020.

Timeline

15 June 2017

Primary endpoint
1 July 2019

29 February 2020

Quick facts

Lead sponsor	Jian-Xin Zhou
Status	Completed
Study type	OBSERVATIONAL
Enrollment	100
Start date	15 June 2017
Primary completion	1 July 2019
Estimated completion	29 February 2020
Sites	1 location across China

Conditions studied

Brain Injuries — all drugs for Brain Injuries →
Mechanical Ventilation — all drugs for Mechanical Ventilation →

Sponsor

Jian-Xin Zhou

Who can join

18 and older, any sex, with Brain Injuries or Mechanical Ventilation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort. However, patient-ventilator asynchrony, which defined as a mismatch between the patient and ventilator may obfuscate these goals. Studies have shown that a high incidence of asynchrony (asynchrony index \> 10%) is associated with prolonged mechanical ventilation and ICU length of stay and high mortality. So far, there have been only a few studies on the epidemiology of asynchrony in brain-injured patients. Investigators conduct a prospective observational study among brain-injured patients to determine the prevalence, risk factors and outcomes of patient-ventilator asynchrony. Esophageal pressure monitoring, a surrogate for pleural pressure, combined with airway pressure and flow waveforms is used to detect patient-ventilator asynchrony.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Patient-ventilator asynchrony in acute brain-injured patients: a prospective observational study.
Luo XY, He X, Zhou YM, Wang YM, et al · · 2020 · cited 15× · PMID 33074406 · DOI 10.1186/s13613-020-00763-8
Validation of the flow index to detect low inspiratory effort during pressure support ventilation.
Miao MY, Chen W, Zhou YM, Gao R, et al · · 2022 · cited 13× · PMID 36161543 · DOI 10.1186/s13613-022-01063-z
ESICM LIVES 2019 : Berlin, Germany. 28 September - 2 October 2019.
· 2019 · cited 8× · PMID 31559498 · DOI 10.1186/s40635-019-0265-y
Ineffective Effort in Patients With Acute Brain Injury Undergoing Invasive Mechanical Ventilation.
Luo XY, He X, Zhou YM, Zhou JF, et al · · 2023 · cited 4× · PMID 36997326 · DOI 10.4187/respcare.10596
Reverse triggering in patients with acute brain injury undergoing controlled ventilation.
Luo XY, Zhou YM, Zhou J, He X, et al · · 2024 · PMID 39552855 · DOI 10.21037/jtd-24-694

Verify or expand the search:

Other recruiting trials for Brain Injuries

Currently open trials in the same condition.

NCT06607523 — The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms · NA · recruiting
NCT06873477 — Evaluation of Patients Affected by Traumatic and Hypoxic-ischemic Brain Injury · recruiting
NCT06511804 — Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Pa · recruiting
NCT06863025 — Effects of Neurofeedback Training on Attentional Deficits in Patients With Acquired Brain Injury · NA · active not recruiting
NCT06571032 — Electroencephalography in the Management of Neuroelectric Stimulation in Patients With Severe Traumatic Brain Injuries · recruiting

Other Jian-Xin Zhou trials

Trials by the same sponsor.

NCT07129174 — Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways · not yet recruiting
NCT06968793 — Use of Endotracheal Tube Cuff Pressure to Assess Inspiratory Effort During Pressure Support Ventilation · NA · completed
NCT06970990 — Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments · NA · recruiting
NCT06816706 — Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials · NA · recruiting
NCT06816745 — Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03212482 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Jian-Xin Zhou
Last refreshed: 29 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03212482.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing