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NCT03205514: SHERLOCK
Multimodality Investigation of Intermediate Culprit Lesion With Negative FFR in NSTE-ACS
trial testing NSTE-ACS with intermediate stenosis and negative FFR in Myocardial Ischemia in 35 participants. Completed in 28 April 2021.
5 June 2018
Quick facts
| Lead sponsor | University Hospital of Ferrara |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 35 |
| Start date | 28 June 2017 |
| Primary completion | 5 June 2018 |
| Estimated completion | 28 April 2021 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- NSTE-ACS with intermediate stenosis and negative FFR
Conditions studied
- Myocardial Ischemia — all drugs for Myocardial Ischemia →
Sponsor
University Hospital of Ferrara
Who can join
18 and older, any sex, with Myocardial Ischemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ten-fifteen percent of acute coronary syndromes without ST-segment elevation (NSTE-ACS) are caused by intermediate lesions without signs of unstable plaque. In this subset of patients, fractional flow reserve (FFR) has some drawbacks and may not be always able to predict outcome, especially when negative (above 0.80). In this particular nique of patients, advanced imaging techniques are suggested by International guidelines. However, it is actually unknown how these techniques may impact treatment strategies. With the present study, the investigators want to characterize the mechanism of disease in this particular subset of patients through multimodality imaging (intravascular ultrasound-near infrared spectroscopy (IVUS-NIRS), optical coherence tomography (OCT)) in order to understand the proper treatment.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03205514
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03205514 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital of Ferrara
- Last refreshed: 29 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03205514.
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