Last reviewed · How we verify
NCT06570759: DIFOCCULT-3
Time for a Diagnostic Paradigm Shift From STEMI/NSTEMI to OMI/NOMI
NA trial testing Early intervention for OMI in Myocardial Infarction in 6,000 participants. Participants enrolled and being followed up; not accepting new ones.
1 September 2025
Quick facts
| Lead sponsor | Başakşehir Çam & Sakura City Hospital |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 6,000 |
| Start date | 1 October 2024 |
| Primary completion | 1 September 2025 |
| Estimated completion | 1 September 2026 |
| Sites | 18 locations across Turkey (Türkiye) |
Drugs / interventions tested
- Early intervention for OMI
- Standard early intervention for STEMI
- Standard delayed intervention for NSTEMI
Conditions studied
- Myocardial Infarction — all drugs for Myocardial Infarction →
- Myocardial Ischemia — all drugs for Myocardial Ischemia →
- Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
- Diagnosis — all drugs for Diagnosis →
Sponsor
Başakşehir Çam & Sakura City Hospital
Who can join
Adults 18 to 99, any sex, with Myocardial Infarction or Myocardial Ischemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators hypothesize that occlusion myocardial infarction(MI)/non-occlusion MI approach to MI treatment will better predict acute coronary occlusion on coronary angiography, better limit infarct size, better preserve left ventricular function and result in lower long-term adverse cardiac events (all cause mortality, all cause rehospitalization) compared to standard ST-elevation/non-ST-elevation MI paradigm.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A Diagnostic Paradigm Shift in Acute Myocardial Infarction: Rationale and Design of the DIFOCCULT-3 Trial.
Aslanger EK, Aggül B, Yıldırımtürk Ö, Karabay CY, et al · · 2025 · cited 5× · PMID 41128712 · DOI 10.1016/j.jacadv.2025.102227 -
Bifascicular Block Associated With Myocardial Infarction: A Marker of Proximal Left Anterior Descending Artery Occlusion Confirmed by the Artificial Intelligence-Based Smartphone App Queen of Hearts.
Granata LG, Russo F, Giubilato S, Scarabelli M, et al · · 2025 · cited 1× · PMID 41458651 · DOI 10.7759/cureus.97853
Verify or expand the search:
- PubMed search for NCT06570759
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Myocardial Infarction
Currently open trials in the same condition.
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- NCT07402642 — Effect of Early Educational Intervention on Cardiovascular Risk Factors After Acute Coronary Syndrome · NA · recruiting
- NCT07301034 — A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, · Phase 3 · recruiting
- NCT07142265 — Evaluation of 1-Year Clinical Outcomes With Early Inclisiran Initiation in Post-MI Patients · recruiting
- NCT07138911 — Effect of Home-based Exercise Plan Mediated by Use of Digital Health App on Kinesiophobia and Functional Capacity · NA · recruiting
Other Başakşehir Çam & Sakura City Hospital trials
Trials by the same sponsor.
- NCT07403682 — M-TAPA vs ESPB for Postoperative Analgesia After Laparoscopic Cholecystectomy · NA · not yet recruiting
- NCT07199049 — Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia · not yet recruiting
- NCT07194707 — Effect of Operating Room Noise on BIS and Hemodynamics Under General Anesthesia · not yet recruiting
- NCT07327125 — Effect of Skin Closure Techniques on Body Image in Women Undergoing Gynecologic Surgery · NA · recruiting
- NCT07453641 — White Noise and Crying Duration After Invasive Procedures in Infants · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06570759 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Başakşehir Çam & Sakura City Hospital
- Last refreshed: 3 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06570759.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing