NCT03185962 (POSE) is a clinical trial in Intubation, sponsored by Osaka University.

Who is sponsoring NCT03185962?

NCT03185962 is sponsored by Osaka University.

What condition does NCT03185962 study?

NCT03185962 studies Intubation, Extubation, Weaning, Mechanical Ventilation, Liberation From Mechanical Ventilation, Critical Care.

Is NCT03185962 still recruiting?

NCT03185962 is currently completed. Last updated 26 January 2021.

Last reviewed 2021-01-26 · How we verify

NCT03185962: POSE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Predictors Of Successful Extubation in Critically Ill Patients: Multicentre Observational Study

Completed Last updated 26 January 2021

What this trial tests

trial in Intubation in 499 participants. Completed in 25 August 2020.

Timeline

1 May 2017

Primary endpoint
31 October 2019

25 August 2020

Quick facts

Lead sponsor	Osaka University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	499
Start date	1 May 2017
Primary completion	31 October 2019
Estimated completion	25 August 2020
Sites	1 location across Japan

Conditions studied

Intubation — all drugs for Intubation →
Extubation — all drugs for Extubation →
Weaning — all drugs for Weaning →
Mechanical Ventilation — all drugs for Mechanical Ventilation →

Sponsor

Osaka University

Who can join

18 and older, any sex, with Intubation or Extubation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Extubation failure can directly worsen patient outcomes. Therefore, the decision to extubate is a critical moment during an intensive care unit (ICU) stay. The decision to extubate is usually made after a weaning readiness test involving spontaneous breathing on a T-piece or low levels of ventilatory assistance. However, extubation failure still occurs in 10 to 20% of patients. The investigators focused on previously reported physiological risk factors, and were able to obtain from common clinical practice: 1) age, 2) underlying cardiovascular disease, 3) underlying respiratory disease or occurrence of pneumonia, 4) rapid shallow breathing index (RSBI), 5) positive fluid balance during the previous 24 hours, 6) the ratio of arterial oxygen partial pressure to fractional inspired oxygen, 7) Glasgow Coma Scale, 8) respiratory tract secretions. The investigators aimed to assess the incidence and risk factors for extubation failure among critically ill patients who passed the 30 min spontaneous breathing test (SBT) using a low level of pressure support (PS) with positive end-expiratory pressure (PEEP), in a prospective multicenter study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Prediction Model of Extubation Outcomes in Critically Ill Patients: A Multicenter Prospective Cohort Study.
Tanaka A, Kabata D, Hirao O, Kosaka J, et al · · 2022 · cited 5× · PMID 35566646 · DOI 10.3390/jcm11092520

Verify or expand the search:

Other recruiting trials for Intubation

Currently open trials in the same condition.

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Other Osaka University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03185962 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Osaka University
Last refreshed: 26 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03185962.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing