NCT03169127 is a Phase 4 clinical trial of Ibuprofen 600 mg in Pain, sponsored by University of Sao Paulo.

Who is sponsoring NCT03169127?

NCT03169127 is sponsored by University of Sao Paulo.

What drugs are being tested in NCT03169127?

Interventions in NCT03169127: Ibuprofen 600 mg.

What condition does NCT03169127 study?

NCT03169127 studies Pain, Other Surgical Procedures, Impacted Third Molar Tooth.

Is NCT03169127 still recruiting?

NCT03169127 is currently status unknown. Last updated 12 July 2019.

Last reviewed 2019-07-12 · How we verify

NCT03169127

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Pharmacogenetic of Ibuprofen After Lower Third Molar Surgeries

Status unknown Phase 4 Last updated 12 July 2019

What this trial tests

Phase 4 trial testing Ibuprofen 600 mg in Pain in 200 participants. Status unknown.

Timeline

1 April 2016

Primary endpoint
30 July 2018

1 July 2020

Quick facts

Lead sponsor	University of Sao Paulo
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	200
Start date	1 April 2016
Primary completion	30 July 2018
Estimated completion	1 July 2020
Sites	1 location across Brazil

Drugs / interventions tested

Ibuprofen 600 mg — full drug profile →

Conditions studied

Pain — all drugs for Pain →
Other Surgical Procedures — all drugs for Other Surgical Procedures →
Impacted Third Molar Tooth — all drugs for Impacted Third Molar Tooth →

Sponsor

University of Sao Paulo

Who can join

Adults 18 to 60, any sex, with Pain or Other Surgical Procedures. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present clinical trial randomized will be to assess the link between the different haplotypes of CYP2C8 and CYP2C9 genes and the clinical efficacy of ibuprofen after lower third molar extractions. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 200 healthy volunteers underwent removal of one lower third molar, under local anesthesia with articaine 4% (1:200,000 adrenaline) will be genotyped and phenotyped for these genes and their postoperative records with all data collected will be compared with the haplotypes found in the Brazilian population.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Multifocal Analysis of Acute Pain After Third Molar Removal.
Weckwerth GM, Dionísio TJ, Costa YM, Zupelari-Gonçalves P, et al · · 2021 · cited 8× · PMID 33935738 · DOI 10.3389/fphar.2021.643874
CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction.
Weckwerth GM, Dionísio TJ, Costa YM, Colombini-Ishiquiriama BL, et al · · 2021 · cited 7× · PMID 33205280 · DOI 10.1007/s00228-020-03046-0

Verify or expand the search:

Other trials of Ibuprofen 600 mg

Trials testing the same drug.

NCT06937853 — Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management · NA · recruiting
NCT06247462 — Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat · Phase 1 · completed
NCT05548582 — Reduced Opioid Prescription After Laparoscopic Hysterectomy · NA · active not recruiting
NCT05355441 — Pain Multidisciplinar Intervention in Major Trauma Patients · completed
NCT04813991 — Pain Control Without Opioids · Phase 3 · withdrawn

Other recruiting trials for Pain

Currently open trials in the same condition.

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Other University of Sao Paulo trials

Trials by the same sponsor.

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NCT07522554 — Lavender and Lemongrass Aromatherapy for Pain and Anxiety in Labor: A Randomized Trial · NA · active not recruiting
NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
NCT07445178 — Piecemeal Resection and Advanced Histology Independently Predict Local Recurrence After Colorectal Snare-based Endoscopi · completed
NCT07170007 — Physiotherapeutic Protocol Compared to Usual Care in the Treatment of Primiparas After Perineal Trauma · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03169127 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Sao Paulo
Last refreshed: 12 July 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03169127.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing