NCT03157102: CANULASTHM

High Flow Nasal Cannula in Children With Status Asthmaticus

Completed NA Last updated 26 September 2023

What this trial tests

NA trial testing HFNC in Status Asthmaticus in 272 participants. Completed in 29 June 2023.

Timeline

8 August 2018

Primary endpoint
29 June 2023

29 June 2023

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	272
Start date	8 August 2018
Primary completion	29 June 2023
Estimated completion	29 June 2023
Sites	14 locations across France

Drugs / interventions tested

• HFNC
• Standard Oxygen Treatment

Conditions studied

• Status Asthmaticus — all drugs for Status Asthmaticus →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

Adults 6 Months to 17, any sex, with Status Asthmaticus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In France, over 2.5 million people suffer from asthma, including one-third of children. This is the chronic respiratory disease leading to the highest rate of hospitalization. The conventional oxygen delivery means in children are the non-rebreather face mask or low flow nasal cannula (standard oxygen therapy - SOT). New non-invasive ventilatory support systems such as High Flow Nasal Cannula (HFNC) are emerging. These are nasal cannulas allowing the delivery of a high air (or oxygen) flow, exceeding the inspiratory flow of patients with acute respiratory failure, allowing to deliver a slight positive expiratory pressure while ensuring humidification and warming of the airways. Aerosol administration is also possible with excellent efficiency and without interrupting respiratory assistance. Physiological data and clinical studies in other pathologies suggest the interest of this technique during the asthma attack, but no comparative study currently exists in this indication. The HFNCs could have their place upstream of Non Invasive Ventilation (NIV), thus replacing non-rebreather face mask sometimes not tolerated by the children. The investigators's hypothesis is that HFNCs could improve patients' health faster, reduce the use of other ventilatory assistance (NIV, invasive ventilation) and reduce the duration of hospitalization in intensive care units or continuous monitoring units (CMU).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. High flow nasal cannula use is associated with increased hospital length of stay for pediatric asthma.
   Rogerson C, Owora A, He T, Carroll A, et al · · 2023 · cited 13× · PMID 37530483 · DOI 10.1002/ppul.26617