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NCT03153241
Subglottic Secretion Culture in Predicting Tracheal Microbial Flora
trial testing No intervention in Pneumonia in 100 participants. Completed in 20 November 2018.
20 October 2018
Quick facts
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 20 October 2017 |
| Primary completion | 20 October 2018 |
| Estimated completion | 20 November 2018 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- No intervention
Conditions studied
- Pneumonia — all drugs for Pneumonia →
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who can join
18 and older, any sex, with Pneumonia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ventilator-associated pneumonia (VAP) continues to be a major cause of morbidity and mortality in the intensive care unit (ICU). Microaspiration of subglottic secretions accumulated above the endotracheal tube cuff is the primary route of bacterial entry into the lower respiratory tract.Therefore, removal of secretions from the subglottic spacehas been recommended as a preventive strategy to avoid microaspiration and VAP. In this context, whereas considerable literature exists on the use subglottic secretion drainage (SSD) in patients at risk for developing VAP, there is a lack of data on the bacterial growth in the subglottic fluid above the cuff. The primary objective of the study will be to assess the value of subglottic secretion culture in predicting microbial flora of endotracheal aspirate samplein patients admitted to our ICU and under invasive mechanical ventilation for at least 48 hours. Secondary end-point will be to estimate the predictive value of subglottic secretion culture in identifying bacterial pathogens in the sub-population of patients who will develop VAP.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Microbiologic surveillance through subglottic secretion cultures during invasive mechanical ventilation: a prospective observational study.
Bello G, Bisanti A, Giammatteo V, Montini L, et al · · 2020 · cited 3× · PMID 32516641 · DOI 10.1016/j.jcrc.2020.05.013
Verify or expand the search:
- PubMed search for NCT03153241
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03153241 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Last refreshed: 25 September 2024
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