NCT03146585 is a clinical trial of PBR assessment in Critical Illness, sponsored by University Hospital Hradec Kralove.

Who is sponsoring NCT03146585?

NCT03146585 is sponsored by University Hospital Hradec Kralove.

What drugs are being tested in NCT03146585?

Interventions in NCT03146585: PBR assessment.

What condition does NCT03146585 study?

NCT03146585 studies Critical Illness.

Is NCT03146585 still recruiting?

NCT03146585 is currently completed. Last updated 30 March 2020.

Are results published for NCT03146585?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2020-03-30 · How we verify

NCT03146585

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Glycocalyx Damage in Critically Ill Patients

Completed Results posted Last updated 30 March 2020

What this trial tests

trial testing PBR assessment in Critical Illness in 40 participants. Completed in 30 June 2018.

Timeline

1 November 2015

Primary endpoint
31 December 2017

30 June 2018

Quick facts

Lead sponsor	University Hospital Hradec Kralove
Status	Completed
Study type	OBSERVATIONAL
Enrollment	40
Start date	1 November 2015
Primary completion	31 December 2017
Estimated completion	30 June 2018
Sites	1 location across Czechia

Drugs / interventions tested

PBR assessment

Conditions studied

Critical Illness — all drugs for Critical Illness →

Sponsor

University Hospital Hradec Kralove

Who can join

18 and older, any sex, with Critical Illness. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Perfused Boundary Region (PBR) in One Week Primary · One week on ICU

PBR is an indirect measure of assessment of the endothelial glycocalyx thickness in sublingual microcirculation.

Group	Value	95% CI
Patients on Artificial Ventilation	1.95	1.77 – 2.12
Patients on Renal Replacement Therapy	1.97	1.75 – 2.12
Patients With Targeted Temperature Management	2.02	1.71 – 2.15

Sponsor's own description

The hypothesis to be tested: GCX damage and its dynamics correlate to various patient related factors and to using organ-supporting measures. There is a correlation between length of organ support and GCX damage. The aim of the study: Evaluation of the relationship between GCX damage and duration of various organ supporting measures. Type of the study: Observational. Subjects: Adult patients admitted to ICU and requiring organ supporting therapy. Sample size: We plan enrollment of 75 patients on invasive ventilatory support in the duration of least 5 days, 50 patients on renal supporting therapy lasting at least 5 days and 20 patients with target temperature management for neuroprotection. Intervention: none Data to be recorded and analysed: Demographics, type of patients (trauma, post surgical, medical, after cardiac arrest), severity score - Apache II, SOFA, fluid balance, presence of delirium, clinical outcome, sublingual microcirculation by SDF imaging at time points: before or at the start of organ support, after 24 hours (day 1), day 3, 5, 7 and/or at discharge or before death, microcirculatory data, and Perfused Boundary Region.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Critical Illness

Currently open trials in the same condition.

NCT06189924 — Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients · recruiting
NCT07418242 — Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients · recruiting
NCT07101640 — PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysp · Phase 1, PHASE2 · recruiting
NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting

Other University Hospital Hradec Kralove trials

Trials by the same sponsor.

NCT07415655 — Modulation of Cerebral Ischemia by Albumin · Phase 2 · not yet recruiting
NCT03644641 — The Influence of Prone Position for Spinal Surgery on Visual Acuity · NA · not yet recruiting
NCT06894927 — Hearing Screening in Adults Over 50 Years Old · NA · enrolling by invitation
NCT05399602 — The Role of Neurofilament Light (NfL) in Patients With Hydrocephalus · NA · completed
NCT06083233 — Role of Brain Specific Biomarkers in Hydrocephalus · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03146585 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Hradec Kralove
Last refreshed: 30 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03146585.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing