Who is sponsoring NCT03121391?

NCT03121391 is sponsored by Wayne State University.

What drugs are being tested in NCT03121391?

Interventions in NCT03121391: Ventilator withdrawal algorithm.

What condition does NCT03121391 study?

NCT03121391 studies Critical Care, Palliative Care.

Is NCT03121391 still recruiting?

NCT03121391 is currently completed. Last updated 29 November 2022.

Last reviewed 2022-11-29 · How we verify

NCT03121391

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

An Algorithmic Approach to Ventilator Withdrawal at the End of Life

Completed NA Last updated 29 November 2022

What this trial tests

NA trial testing Ventilator withdrawal algorithm in Critical Care in 165 participants. Completed in 31 July 2022.

Timeline

20 April 2017

Primary endpoint
31 July 2022

31 July 2022

Quick facts

Lead sponsor	Wayne State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	supportive care
Enrollment	165
Start date	20 April 2017
Primary completion	31 July 2022
Estimated completion	31 July 2022
Sites	5 locations across United States

Drugs / interventions tested

Ventilator withdrawal algorithm

Conditions studied

Critical Care — all drugs for Critical Care →
Palliative Care — all drugs for Palliative Care →

Sponsor

Wayne State University

Who can join

18 and older, any sex, with Critical Care or Palliative Care. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The proposed study is an important, under-investigated area of ICU care for terminally ill patients undergoing terminal ventilator withdrawal. The proposed research has relevance to public health because an algorithmic approach to the ventilator withdrawal process will enhance clinicians' ability to conduct the process while assuring patient comfort, using opioids and/or benzodiazepines effectively.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effectiveness of an Algorithmic Approach to Ventilator Withdrawal at the End of Life: A Stepped Wedge Cluster Randomized Trial.
Campbell ML, Yarandi HN. · · 2024 · cited 9× · PMID 37594769 · DOI 10.1089/jpm.2023.0128
Discussion on Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study).
Campbell ML, Robert R, Reignier J. · · 2018 · cited 1× · PMID 29285585 · DOI 10.1007/s00134-017-5037-0

Verify or expand the search:

Other recruiting trials for Critical Care

Currently open trials in the same condition.

NCT06526598 — Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial · NA · recruiting
NCT06457555 — Knowledge Levels and Experiences of Intensive Care Nurses on the Prevention of Pressure Sores: Mixed Method · active not recruiting
NCT06970990 — Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments · NA · recruiting
NCT06816706 — Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials · NA · recruiting
NCT06862700 — Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients · recruiting

Other Wayne State University trials

Trials by the same sponsor.

NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
NCT07123467 — Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder · Phase 3 · recruiting
NCT07222306 — Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study · enrolling by invitation
NCT05684978 — Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus · Phase 4 · terminated
NCT06381180 — Warrior CARE: Cannabis Behavioral Health · Phase 1, PHASE2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03121391 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Wayne State University
Last refreshed: 29 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03121391.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing