NCT03116165

Cognitive-Behavioural Therapy as a Preventive Treatment for Post Traumatic Stress Disorder

Terminated NA Last updated 17 May 2018

What this trial tests

NA trial testing Modified prolonged exposure therapy in Post Traumatic Stress Disorder in 352 participants. Terminated before completion.

Timeline

18 April 2017

Primary endpoint
11 December 2017

11 December 2017

Quick facts

Lead sponsor	Karolinska Institutet
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	352
Start date	18 April 2017
Primary completion	11 December 2017
Estimated completion	11 December 2017
Sites	1 location across Sweden

Drugs / interventions tested

• Modified prolonged exposure therapy
• Attention control

Conditions studied

• Post Traumatic Stress Disorder — all drugs for Post Traumatic Stress Disorder →

Sponsor

Karolinska Institutet

Who can join

16 and older, any sex, with Post Traumatic Stress Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will examine the use of modified prolonged exposure therapy in trauma patients recently exposed to trauma in an emergency room to prevent the onset of post-traumatic stress disorder.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
   Bragesjö M, Arnberg FK, Andersson E. · · 2021 · cited 3× · PMID 34029328 · DOI 10.1371/journal.pone.0251898
2. Exploring scalable assessment methods for terminated trials in ClinicalTrials.gov: A cohort analysis of German and Californian trials.
   Yerunkar SS, Carlisle BG, Franzen DL, Salholz-Hillel M, et al · · 2026 · PMID 41984886 · DOI 10.1371/journal.pone.0346608