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NCT03114917: CARMS
Cognitive AppRoaches to coMbatting Suicidality
NA trial testing Cognitive AppRoaches to coMbatting Suicidality (CARMS) in Psychosis in 329 participants. Completed in 27 January 2022.
27 January 2022
Quick facts
| Lead sponsor | University of Manchester |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 329 |
| Start date | 12 May 2017 |
| Primary completion | 27 January 2022 |
| Estimated completion | 27 January 2022 |
| Sites | 4 locations across United Kingdom |
Drugs / interventions tested
- Cognitive AppRoaches to coMbatting Suicidality (CARMS)
Conditions studied
- Psychosis — all drugs for Psychosis →
- Suicide Prevention — all drugs for Suicide Prevention →
- Suicidality — all drugs for Suicidality →
Sponsor
University of Manchester
Who can join
18 and older, any sex, with Psychosis or Suicide Prevention. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a randomised controlled trial which investigates the effectiveness of CARMS (Cognitive AppRoaches to coMbatting Suicidality) therapy in reducing suicidal thoughts and how well CARMS works in practice within the NHS. The trial will compare two groups of people with psychosis who are using NHS mental health services. One group will carry on with their usual treatment. The other group will be offered 24 weekly sessions of CARMS therapy, plus their usual treatment.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
A psychological intervention for suicide applied to non-affective psychosis: the CARMS (Cognitive AppRoaches to coMbatting Suicidality) randomised controlled trial protocol.
Gooding PA, Pratt D, Awenat Y, Drake R, et al · · 2020 · cited 19× · PMID 32546129 · DOI 10.1186/s12888-020-02697-8 -
The interplay between suicidal experiences, psychotic experiences and interpersonal relationships: a qualitative study.
Gooding P, Haddock G, Harris K, Asriah M, et al · · 2023 · cited 9× · PMID 38001403 · DOI 10.1186/s12888-023-05164-2 -
Underlying mechanisms and efficacy of a suicide-focused psychological intervention for psychosis, the Cognitive Approaches to Combatting Suicidality (CARMS): a multicentre, assessor-masked, randomised controlled trial in the UK.
Gooding P, Pratt D, Edwards D, Awenat Y, et al · · 2025 · cited 3× · PMID 39827886 · DOI 10.1016/s2215-0366(24)00399-7 -
The Relationship between the Therapeutic Alliance and Suicidal Experiences in People with Psychosis Receiving Therapy.
Huggett C, Gooding P, Haddock G, Pratt D. · · 2021 · cited 2× · PMID 34682451 · DOI 10.3390/ijerph182010706 -
The dynamic interplay between anxiety-related, psychotic, and suicidal experiences: a qualitative study.
Gooding P, Harris K, Peters S, Haddock G. · · 2025 · cited 1× · PMID 41257613 · DOI 10.1186/s12888-025-07547-z -
A psychological talking therapy for suicidality in people experiencing non-affective psychosis: Mechanism and efficacy outcomes of the CARMS (Cognitive AppRoaches to coMbatting Suicidality) randomised controlled trial
Gooding P, Awenat Y, Drake R, Emsley R, et al · · 2026 · PMID 41812003 -
The interplay between suicidal experiences, psychotic experiences and interpersonal relationships: a qualitative study
Gooding P, Haddock G, Harris K, Asriah M, et al · · 2023 · DOI 10.21203/rs.3.rs-2919728/v1
Verify or expand the search:
- PubMed search for NCT03114917
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03114917 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Manchester
- Last refreshed: 10 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03114917.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing