NCT03092908

Mature Vinegar Prophylaxis Against Recurrent Calcium Oxalate Nephrolithiasis

Status unknown NA Last updated 3 July 2018

What this trial tests

NA trial testing mature vinegar in Nephrolithiasis in 80 participants. Status unknown.

Timeline

22 March 2017

Primary endpoint
31 December 2021

31 December 2022

Quick facts

Lead sponsor	The First Affiliated Hospital of Guangzhou Medical University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	80
Start date	22 March 2017
Primary completion	31 December 2021
Estimated completion	31 December 2022
Sites	1 location across China

Drugs / interventions tested

• mature vinegar
• placebo (water)

Conditions studied

• Nephrolithiasis — all drugs for Nephrolithiasis →

Sponsor

The First Affiliated Hospital of Guangzhou Medical University

Who can join

18 and older, any sex, with Nephrolithiasis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Kidney stones are one of the most common disorders of the urinary tract and cause a great deal of morbidity and economic loss. Because of the high recurrence rate, researchers are interested in finding medicinal therapies to prevent kidney stone recurrence. Vinegar is consumed worldwide as a food condiment and preservative. The mature vinegar, also called black vinegar, is an inky-black vinegar aged for a malty, woody, and smoky flavor. It is popular in the north of China as a dipping sauce, particularly for dumplings.

Some studies promote vinegar for its medicinal properties, as a tonic which may lower blood pressure and cholesterol level. Our national epidemiological data in China showed that consumed more mature vinegar was associated with decreased risk of kidney stones formations. Furthermore, our previous in vivo study found that mature vinegar could inhibit renal calcium oxalate crystals formation in rat model. These findings inspire us to clarify the nephrolithiasis prevention effect of mature vinegar in a clinical trial. In this study, investigators would like to examine the efficacy of mature vinegar prophylaxis for preventing recurrent calcium oxalate nephrolithiasis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Dietary vinegar prevents kidney stone recurrence via epigenetic regulations.
   Zhu W, Liu Y, Lan Y, Li X, et al · · 2019 · cited 53× · PMID 31202812 · DOI 10.1016/j.ebiom.2019.06.004