NCT03092297 (INOX ICU-2) is a clinical trial in Critical Care, sponsored by Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research.

Who is sponsoring NCT03092297?

NCT03092297 is sponsored by Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research.

What condition does NCT03092297 study?

NCT03092297 studies Critical Care, Anemia, Erythrocyte Transfusion, Oxygen, Mitochondria.

Is NCT03092297 still recruiting?

NCT03092297 is currently terminated. Last updated 19 January 2023.

Last reviewed 2023-01-19 · How we verify

NCT03092297: INOX ICU-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Insufficient Cellular Oxygen in ICU Patients With Anaemia

Terminated Last updated 19 January 2023

What this trial tests

trial in Critical Care in 103 participants. Terminated before completion.

Timeline

16 May 2017

Primary endpoint
1 July 2021

1 December 2022

Quick facts

Lead sponsor	Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	103
Start date	16 May 2017
Primary completion	1 July 2021
Estimated completion	1 December 2022
Sites	2 locations across Netherlands

Conditions studied

Critical Care — all drugs for Critical Care →
Anemia — all drugs for Anemia →
Erythrocyte Transfusion — all drugs for Erythrocyte Transfusion →
Oxygen — all drugs for Oxygen →

Sponsor

Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research

Who can join

18 and older, any sex, with Critical Care or Anemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is whether the mitochondrial oxygenation tension (mitoPO2) is a feasible and reliable tool in ICU patients with anaemia undergoing red cell transfusion to ultimately personalize blood transfusion decisions in the ICU.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Study protocol and pilot results of an observational cohort study evaluating effect of red blood cell transfusion on oxygenation and mitochondrial oxygen tension in critically ill patients with anaemia: the INsufficient Oxygenation in the Intensive Care Unit (INOX ICU-2) study.
Baysan M, Arbous MS, Mik EG, Juffermans NP, et al · · 2020 · cited 8× · PMID 32423938 · DOI 10.1136/bmjopen-2019-036351
Mitochondrial oxygen tension in critically ill patients receiving red blood cell transfusions: a multicenter observational cohort study.
Baysan M, Hilderink B, van Manen L, Caram-Deelder C, et al · · 2024 · cited 5× · PMID 38976096 · DOI 10.1186/s40635-024-00646-3

Verify or expand the search:

Other recruiting trials for Critical Care

Currently open trials in the same condition.

NCT06526598 — Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial · NA · recruiting
NCT06457555 — Knowledge Levels and Experiences of Intensive Care Nurses on the Prevention of Pressure Sores: Mixed Method · active not recruiting
NCT06970990 — Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments · NA · recruiting
NCT06816706 — Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials · NA · recruiting
NCT06862700 — Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients · recruiting

Other Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research trials

Trials by the same sponsor.

NCT04626661 — Mitochondrial Oxygen Measurement Variability in Critically Ill Patients (INOX Variability Study) · completed
NCT06176105 — Mortality After Transfusion of Ever-pregnant Donor Red Blood Cells · completed
NCT03842722 — Insufficient Oxygenation in Septic Patients · completed
NCT03505086 — Bleeding In Thrombocytopenia Explained · recruiting
NCT03110887 — Monitoring Outcome in Neonatal Thrombocytopenia · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03092297 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Last refreshed: 19 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03092297.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing