Adults 65 to 99, any sex, with Older Adults or Physical Function. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Curcumin and Physical Function -WalkingPrimary· Change in walking speed (meters/second) from Baseline and 3 months
To examine the effects of dietary supplementation with curcumin on changes in physical function walking speed- 400meter walk test.
Group
Value
95% CI
Curcumin
0.014
± 0.090
Placebo
0.103
± 0.10
Curcumin and Physical Function - Hand GripPrimary· Change in grip strength (kilograms) from Baseline and 3 months
To examine the effects of dietary supplementation with curcumin on changes in physical function grip strength- hand dynamometer
Group
Value
95% CI
Curcumin
0.63
± 4.90
Placebo
-0.25
± 3.14
Curcumin and Cognitive Function - Attention & MemorySecondary· Change in attention from Baseline and 3 months
To examine the effects of dietary supplementation with curcumin on cognitive performance mini-mental state examination. 30 points max. The lower, the worse score.
Group
Value
95% CI
Curcumin
0.33
± 3.94
Placebo
-2.75
± 5.09
Curcumin and PainSecondary· Baseline and 3 months
To examine the effects of dietary supplementation with curcumin on pain symptoms (pain scale 0-10 with 10 being the worst)
Baseline
Group
Value
95% CI
Curcumin
0.97
± 1.3
Placebo
1.3
± 1.7
90 Days
Group
Value
95% CI
Curcumin
0.2
± 0.4
Placebo
1.6
± 1.7
Curcumin and Inflammation - Interleukin-6Secondary· From Baseline and 3 months
To examine the effects of dietary supplementation with curcumin on markers of systemic inflammation Interleukin-6 (ng/ml)
Baseline
Group
Value
95% CI
Curcumin
3.1
± 1.4
Placebo
2.7
± 1.7
90 Days
Group
Value
95% CI
Curcumin
3.4
± 1.5
Placebo
3.6
± 1.5
Sponsor's own description
This placebo-controlled RCT tests whether dietary supplementation with curcumin maintains or improves cognitive and physical function in older adults who are at high risk of functional decline due existing (mild) functional impairments and elevated biomarkers of inflammation and explore the association between functional changes and changes in biological indicators of active inflammation.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
NCT07436130 — Curcumin in Critically Ill Patients With Sepsis
· NA
· not yet recruiting
NCT07251985 — Cognitive Effects of Bioavailable Curcumin
· Phase 2
· not yet recruiting
NCT07379177 — Evaluation of the Pharmacokinetics of Curcumin Capsules in Healthy Human
· NA
· not yet recruiting
NCT07523256 — Effect of Curcumin Add-On Therapy on Quality of Life and IL-1β Levels in Patients With Schizophrenia
· NA
· completed
NCT06531863 — Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance
· EARLY_PHASE1
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Florida
Last refreshed: 26 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03085680.