Who is sponsoring NCT03083457?

NCT03083457 is sponsored by Catholic University of the Sacred Heart.

What drugs are being tested in NCT03083457?

Interventions in NCT03083457: Fluid resuscitation or amine administration, General anesthetic, Fluid administration, Low-tidal volume ventilation, Scheduled recruiting maneuvers.

What condition does NCT03083457 study?

NCT03083457 studies Anesthesia, General, Surgery.

Is NCT03083457 still recruiting?

NCT03083457 is currently completed. Last updated 29 January 2021.

Last reviewed 2021-01-29 · How we verify

NCT03083457: PEEP-RM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Physiological Effects of Lung Recruitment During General Anesthesia and Low-tidal Volume Ventilation

Completed NA Last updated 29 January 2021

What this trial tests

NA trial testing Fluid resuscitation or amine administration in Anesthesia, General in 30 participants. Completed in 30 November 2020.

Timeline

20 March 2017

Primary endpoint
30 November 2020

30 November 2020

Quick facts

Lead sponsor	Catholic University of the Sacred Heart
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	30
Start date	20 March 2017
Primary completion	30 November 2020
Estimated completion	30 November 2020
Sites	1 location across Italy

Drugs / interventions tested

Fluid resuscitation or amine administration — full drug profile →
General anesthetic — full drug profile →
Fluid administration — full drug profile →
Low-tidal volume ventilation
Scheduled recruiting maneuvers

Conditions studied

Anesthesia, General — all drugs for Anesthesia, General →
Surgery — all drugs for Surgery →

Sponsor

Catholic University of the Sacred Heart

Who can join

18 and older, any sex, with Anesthesia, General or Surgery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Low-tidal volume ventilation is arising as a tool to optimize the ventilatory management and to improve clinical outcome in patients undergoing general anesthesia for abdominal surgery. A recent large randomized controlled trial failed to detect a significant difference between two different approaches for ensuring adequate lung recruitment (PEEP=12 cmH2O + scheduled recruiting maneuvers vs. PEEP 2 cmH2O) during protective ventilation. Thus, in patients undergoing open abdominal surgery and receiving low-tidal volumes, the effects of different positive end-expiratory pressure (PEEP) levels and recruiting maneuvers remain to be established. Design: prospective, cross-over, physiological trial. PURPOSE To assess the physiological effects of different PEEP levels with or without scheduled recruiting maneuvers in patients undergoing general anesthesia for open abdominal surgery and receiving low-tidal volume ventilation.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Anesthesia, General

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Other Catholic University of the Sacred Heart trials

Trials by the same sponsor.

NCT07476599 — The OB-WELL Project, a Randomized Controlled Trial of an Internet-Based Self-Help System for Psychological Support in Ob · NA · not yet recruiting
NCT07516392 — Study of a Polygenic Risk Score to Predict the Risk of Pancreatic Ductal Adenocarcinoma · NA · not yet recruiting
NCT07140705 — Personalized Virtual Reality for Promoting Well-Being and Psychological Flexibility in General Practitioners · NA · completed
NCT06992453 — Multi-omics Dissection of Gut Microbiome Engraftment During FMT · NA · not yet recruiting
NCT06852183 — Restructuring Body Experience in Anorexia Nervosa: Virtual Reality Functionality-Focused Mirror Exposure · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03083457 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Catholic University of the Sacred Heart
Last refreshed: 29 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03083457.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing