NCT03062241 (CONTRA-HF) is a NA clinical trial of Cryoablation in Atrial Fibrillation, sponsored by Medical University of Silesia.

Who is sponsoring NCT03062241?

NCT03062241 is sponsored by Medical University of Silesia.

What drugs are being tested in NCT03062241?

Interventions in NCT03062241: Cryoablation.

What condition does NCT03062241 study?

NCT03062241 studies Atrial Fibrillation, Severe Heart Failure.

Is NCT03062241 still recruiting?

NCT03062241 is currently status unknown. Last updated 7 November 2017.

Last reviewed 2017-11-07 · How we verify

NCT03062241: CONTRA-HF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ablation of Atrial Fibrillation in Heart Failure Patients

Status unknown NA Last updated 7 November 2017

What this trial tests

NA trial testing Cryoablation in Atrial Fibrillation in 330 participants. Status unknown.

Timeline

23 January 2017

Primary endpoint
31 July 2018

31 July 2019

Quick facts

Lead sponsor	Medical University of Silesia
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	330
Start date	23 January 2017
Primary completion	31 July 2018
Estimated completion	31 July 2019
Sites	1 location across Poland

Drugs / interventions tested

Cryoablation — full drug profile →

Conditions studied

Atrial Fibrillation — all drugs for Atrial Fibrillation →
Severe Heart Failure — all drugs for Severe Heart Failure →

Sponsor

Medical University of Silesia

Who can join

Adults 18 to 75, any sex, with Atrial Fibrillation or Severe Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the study is to evaluate the impact of cryoablation of atrial fibrillation in patients with severe chronic heart failure (CHF) on long term outcome of CHF and efficacy (endurance) of the procedure itself. The study hypothesis is that cryoablation in eligible patients with CHF and ICD/CRT (implantable cardioverter defibrillator / cardiac resynchronization therapy) implants reduce the number of recurrent CHF hospitalizations, mortality, need for mechanical support of LV (left ventricle) and heart transplant (primary endpoint) at 1 year observation in comparison to traditional (pharmacological) treatment..

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Update on management of atrial fibrillation in heart failure: a focus on ablation.
Mulder BA, Rienstra M, Van Gelder IC, Blaauw Y. · · 2022 · cited 26× · PMID 34088767 · DOI 10.1136/heartjnl-2020-318081
Economic Evaluation of Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure With Reduced Ejection Fraction.
Chew DS, Loring Z, Anand J, Fudim M, et al · · 2020 · cited 16× · PMID 33280436 · DOI 10.1161/circoutcomes.120.007094
Atrial Fibrillation Ablation in Patients with Heart Failure: One Size Does Not Fit All.
Mukherjee RK, Williams SE, Niederer SA, O'Neill MD. · · 2018 · cited 10× · PMID 29967679 · DOI 10.15420/aer.2018.11.3
The Evolving Role of Catheter Ablation in Patients With Heart Failure and AF.
Prabhu S, Lim WH, Schilling RJ. · · 2019 · cited 2× · PMID 30918667 · DOI 10.15420/aer.2019.9.2
Long-term Outcome of Pulmonary Vein Isolation Versus Amiodarone Therapy in Patients with Coexistent Persistent AF and Congestive Heart Failure.
Faggioni M, Della Rocca DG, Mohanty S, Trivedi C, et al · · 2020 · cited 1× · PMID 32377383 · DOI 10.15420/cfr.2019.03

Verify or expand the search:

Other trials of Cryoablation

Trials testing the same drug.

NCT07380789 — Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine · NA · recruiting
NCT07306286 — Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-L · Phase 2 · recruiting
NCT07147088 — Cryoablation Combined With SHR-1701 Plus Famitinib in Patients With Advanced Intrahepatic Cholangiocarcinoma. · Phase 2 · not yet recruiting
NCT06991231 — The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty · NA · recruiting
NCT06848881 — Cryoablation vs Thoracoscopic Surgery for GGN · NA · recruiting

Other recruiting trials for Atrial Fibrillation

Currently open trials in the same condition.

NCT07429214 — A Study of VARIPULSE Catheter and TRUPULSE Generator With VARIPULSE Pro Software in Participants With PAF or PsAF · NA · recruiting
NCT07271238 — Feasibility Study on the VERAFEYE Imaging and Navigation System for Guided Catheter Ablation Procedures · NA · recruiting
NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
NCT07428967 — AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function · NA · recruiting
NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting

Other Medical University of Silesia trials

Trials by the same sponsor.

NCT06212674 — Single-stage Pulmonary Vein Isolation Combined With Percutaneous Left Atrial Appendage Occluder Implantation in Patients · Phase 4 · recruiting
NCT06970002 — Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes · NA · not yet recruiting
NCT07137299 — POPQ Associated With Total Laparoscopic Hysterectomy · not yet recruiting
NCT06970041 — To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated · NA · not yet recruiting
NCT07120529 — Minimally Invasive Surgery Versus Open Radical Hysterectomy in Presumably Early Stage Cervical Cancer: a Retrospective M · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03062241 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Silesia
Last refreshed: 7 November 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03062241.

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