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NCT03055585: AWED

Applying Wolbachia to Eliminate Dengue

Terminated NA Last updated 9 June 2020
What this trial tests

NA trial testing Wolbachia-infected Aedes aegypti mosquitoes in Dengue in 8,173 participants. Terminated before completion.

Timeline
8 November 2017
Primary endpoint
18 March 2020
8 April 2020

Quick facts

Lead sponsorGadjah Mada University
PhaseNA
StatusTerminated
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposeprevention
Enrollment8,173
Start date8 November 2017
Primary completion18 March 2020
Estimated completion8 April 2020
Sites1 location across Indonesia

Drugs / interventions tested

Conditions studied

Sponsor

Gadjah Mada University

Who can join

Adults 3 to 45, any sex, with Dengue or Zika Virus Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue.
    Utarini A, Indriani C, Ahmad RA, Tantowijoyo W, et al · · 2021 · cited 435× · PMID 34107180 · DOI 10.1056/nejmoa2030243
  2. Controlling vector-borne diseases by releasing modified mosquitoes.
    Flores HA, O'Neill SL. · · 2018 · cited 221× · PMID 29777177 · DOI 10.1038/s41579-018-0025-0
  3. Establishment of <i>w</i>Mel <i>Wolbachia</i> in <i>Aedes aegypti</i> mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia.
    Ryan PA, Turley AP, Wilson G, Hurst TP, et al · · 2019 · cited 216× · PMID 31667465 · DOI 10.12688/gatesopenres.13061.2
  4. Reduced dengue incidence following deployments of <i>Wolbachia</i>-infected <i>Aedes aegypti</i> in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis.
    Indriani C, Tantowijoyo W, Rancès E, Andari B, et al · · 2020 · cited 129× · PMID 32803130 · DOI 10.12688/gatesopenres.13122.1
  5. Using Wolbachia for Dengue Control: Insights from Modelling.
    Dorigatti I, McCormack C, Nedjati-Gilani G, Ferguson NM. · · 2018 · cited 84× · PMID 29183717 · DOI 10.1016/j.pt.2017.11.002
  6. The AWED trial (Applying Wolbachia to Eliminate Dengue) to assess the efficacy of Wolbachia-infected mosquito deployments to reduce dengue incidence in Yogyakarta, Indonesia: study protocol for a cluster randomised controlled trial.
    Anders KL, Indriani C, Ahmad RA, Tantowijoyo W, et al · · 2018 · cited 64× · PMID 29855331 · DOI 10.1186/s13063-018-2670-z
  7. Update to the AWED (Applying Wolbachia to Eliminate Dengue) trial study protocol: a cluster randomised controlled trial in Yogyakarta, Indonesia.
    Anders KL, Indriani C, Ahmad RA, Tantowijoyo W, et al · · 2020 · cited 28× · PMID 32450914 · DOI 10.1186/s13063-020-04367-2
  8. Cluster-Randomized Test-Negative Design Trials: A Novel and Efficient Method to Assess the Efficacy of Community-Level Dengue Interventions.
    Anders KL, Cutcher Z, Kleinschmidt I, Donnelly CA, et al · · 2018 · cited 26× · PMID 29741576 · DOI 10.1093/aje/kwy099

Verify or expand the search:

Other recruiting trials for Dengue

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