Last reviewed · How we verify
NCT03054324: FFRB
Validation of a Predictive Model of Coronary Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis
trial testing Fractional Flow Reserve in Coronary Stenosis in 132 participants. Status unknown.
31 December 2018
Quick facts
| Lead sponsor | National Heart Centre Singapore |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 132 |
| Start date | 2 September 2016 |
| Primary completion | 31 December 2018 |
| Estimated completion | 31 December 2018 |
| Sites | 2 locations across Singapore |
Drugs / interventions tested
- Fractional Flow Reserve
Conditions studied
- Coronary Stenosis — all drugs for Coronary Stenosis →
Sponsor
National Heart Centre Singapore — full company profile →
Who can join
Adults 21 to 98, any sex, with Coronary Stenosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Coronary fraction flow reserve (FFR), the ratio of the mean coronary pressure distal to a coronary stenosis to the mean aortic pressure during maximal coronary blood flow (hyperemia), defines the hemodynamic significance of coronary artery narrowing. Noninvasive assessment of FFR via a combination of computational fluid dynamics (CFD) and coronary CT angiography CCTA (the so-called FFRCT) has potential. Coronary computed tomographic angiography is a noninvasive test for diagnosis of anatomic coronary stenosis (i.e., narrowing of a blood vessel). A new analytical model of FFR from the general Bernoulli equation (conservation of energy) (FFRB) is simple and has potential. A collaborator group has recently developed a new analytical model to quantify pressure drop, and hence FFR, based on lesion dimensions (i.e., the cross-section area along the lesion and the length of lesion) and coronary flow, with no empirical parameters. The investigators hypothesize that this new model will allow quantification of FFR (FFRB) in a cohort of human patients with intermediate coronary stenosis. The study will compare FFRB with invasive FFR measurements from invasive coronary angiography (ICAG).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Coronary CT Angiography-based Morphologic Index for Predicting Hemodynamically Significant Coronary Stenosis.
Wang C, Leng S, Tan RS, Chai P, et al · · 2023 · cited 7× · PMID 38166346 · DOI 10.1148/ryct.230064 -
Computed Tomography Coronary Angiography and Computational Fluid Dynamics Based Fractional Flow Reserve Before and After Percutaneous Coronary Intervention.
Chandola G, Zhang JM, Tan RS, Chai P, et al · · 2021 · cited 5× · PMID 34557479 · DOI 10.3389/fbioe.2021.739667
Verify or expand the search:
- PubMed search for NCT03054324
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Fractional Flow Reserve
Trials testing the same drug.
- NCT06273293 — Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRI · NA · recruiting
- NCT04975425 — Effects of Guiding Catheter on FFR and NHPR for the Assessment of Coronary Artery Stenoses (Disengage@Rest) · completed
- NCT05896501 — Role of FFR in ACS Patients: Pressure ACS Registry · active not recruiting
- NCT03227588 — Evaluation of the Opsens Fractional Flow Reserve (FFR) Wire as a "Work Horse" Wire · unknown
- NCT02935088 — PRESSUREwire Study · completed
Other recruiting trials for Coronary Stenosis
Currently open trials in the same condition.
- NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
- NCT06542393 — PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG) · Phase 2 · recruiting
- NCT05709652 — Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup · NA · recruiting
- NCT06376630 — Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI · NA · recruiting
- NCT04014140 — iFR Guided Coronary Artery Bypass Grafting Surgery · recruiting
Other National Heart Centre Singapore trials
Trials by the same sponsor.
- NCT06645691 — Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body · Phase 2 · recruiting
- NCT05912218 — REducing Diabetic MacrovascUlar Complications DuE to Peripheral Arterial Disease- REDUCE-PAD · Phase 2 · active not recruiting
- NCT05946174 — Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Car · NA · recruiting
- NCT05775484 — Exercise to Slow Cardiovascular Ageing Progression · recruiting
- NCT07376993 — Pulse Signal Acquisition in Patients With Heart Failure · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03054324 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Heart Centre Singapore
- Last refreshed: 18 October 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03054324.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing