NCT03000413 (MACANUDO) is a Phase 2, PHASE3 clinical trial of Ketamine in Critical Illness, sponsored by Hospital Nossa Senhora da Conceicao.

Who is sponsoring NCT03000413?

NCT03000413 is sponsored by Hospital Nossa Senhora da Conceicao.

What drugs are being tested in NCT03000413?

Interventions in NCT03000413: Ketamine, Fentanyl.

What condition does NCT03000413 study?

NCT03000413 studies Critical Illness, Asthma, Bronchospasm.

Is NCT03000413 still recruiting?

NCT03000413 is currently completed. Last updated 21 May 2024.

Last reviewed 2024-05-21 · How we verify

NCT03000413: MACANUDO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial

Completed Phase 2, PHASE3 Last updated 21 May 2024

What this trial tests

Phase 2, PHASE3 trial testing Ketamine in Critical Illness in 45 participants. Completed in 29 January 2018.

Timeline

4 June 2015

Primary endpoint
16 June 2017

29 January 2018

Quick facts

Lead sponsor	Hospital Nossa Senhora da Conceicao
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	45
Start date	4 June 2015
Primary completion	16 June 2017
Estimated completion	29 January 2018
Sites	1 location across Brazil

Drugs / interventions tested

Ketamine (ketamine) — full drug profile →
Fentanyl (fentanyl) — full drug profile →

Conditions studied

Critical Illness — all drugs for Critical Illness →
Asthma — all drugs for Asthma →
Bronchospasm — all drugs for Bronchospasm →

Sponsor

Hospital Nossa Senhora da Conceicao

Who can join

18 and older, male only, with Critical Illness or Asthma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Despite few scientific evidence that could support the use of ketamine in adult patients undergoing acute bronchospasm requiring mechanical ventilation (MV), ketamine is largely employed in this setting. The aim of this study is therefore assess more definitively the real benefit of using ketamine in patients with severe bronchospasm, requiring ICU stay and need for MV in order to establish or refute the use of this drug as "standard therapy" in these cases.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Negative results for ketamine use in severe acute bronchospasm: a randomised controlled trial.
Nedel W, Costa R, Mendez G, Marin L, et al · · 2020 · cited 8× · PMID 32876408 · DOI 10.5114/ait.2020.97765

Verify or expand the search:

Other trials of Ketamine

Trials testing the same drug.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT06963294 — Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty · NA · not yet recruiting
NCT07294092 — Ketamine and Propofol NeuroImaging · EARLY_PHASE1 · recruiting
NCT07197684 — Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surg · NA · not yet recruiting
NCT06231563 — Ketamine for Veterans With Parkinson's Disease · Phase 2 · recruiting

Other recruiting trials for Critical Illness

Currently open trials in the same condition.

NCT06189924 — Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients · recruiting
NCT07418242 — Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients · recruiting
NCT07101640 — PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysp · Phase 1, PHASE2 · recruiting
NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting

Other Hospital Nossa Senhora da Conceicao trials

Trials by the same sponsor.

NCT07426237 — Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass · Phase 4 · not yet recruiting
NCT07290647 — Prospective Validation of an Artificial Intelligence Tool for Pre-Anesthetic Assessment · not yet recruiting
NCT07067866 — Weaning Approaches for Vasopressin in Sepsis · Phase 3 · recruiting
NCT06404892 — ARISCAT, ASA and LAS VEGAS Risk Scores and the Incidence of Postoperative Pulmonary Complications in Thoracic Surgery · recruiting
NCT06466226 — Complications Associated With Multiple Central Venous Accesses in the Internal Jugular Vein · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03000413 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Nossa Senhora da Conceicao
Last refreshed: 21 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03000413.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing