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NCT02983123: OUT-ACS
One-hour Troponin in a Low-prevalence Population of Acute Coronary Syndrome
trial testing 1-hour hs-cTnT in Non-ST Elevation Myocardial Infarction in 1,750 participants. Completed in 22 October 2018.
22 October 2018
Quick facts
| Lead sponsor | Oslo University Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,750 |
| Start date | 15 November 2016 |
| Primary completion | 22 October 2018 |
| Estimated completion | 22 October 2018 |
| Sites | 1 location across Norway |
Drugs / interventions tested
- 1-hour hs-cTnT
Conditions studied
- Non-ST Elevation Myocardial Infarction — all drugs for Non-ST Elevation Myocardial Infarction →
- Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
- Angina, Unstable — all drugs for Angina, Unstable →
- NSTEMI - Non-ST Segment Elevation MI — all drugs for NSTEMI - Non-ST Segment Elevation MI →
Sponsor
Oslo University Hospital
Who can join
18 and older, any sex, with Non-ST Elevation Myocardial Infarction or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to evaluate if the 1-hour rule-in/rule-out algorithm for a high-sensitivity cardiac troponin T (hs-cTnT) is safe and effective for use in the primary care where the patients have a lower pretest probability of an acute myocardial infarction (MI). During this study troponins will be collected at 0-, 1- and 4/6-hours, where absolute changes in the values will decide whether the patient need hospitalization or not.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Pre-hospital One-Hour Troponin in a Low-Prevalence Population of Acute Coronary Syndrome: OUT-ACS study.
Johannessen TR, Vallersnes OM, Halvorsen S, Larstorp ACK, et al · · 2020 · cited 14× · PMID 32719074 · DOI 10.1136/openhrt-2020-001296 -
Cost-effectiveness of a rule-out algorithm of acute myocardial infarction in low-risk patients: emergency primary care versus hospital setting.
Johannessen TR, Halvorsen S, Atar D, Munkhaugen J, et al · · 2022 · cited 12× · PMID 36271364 · DOI 10.1186/s12913-022-08697-6 -
Comparison of a single high-sensitivity cardiac troponin T measurement with the HEART score for rapid rule-out of acute myocardial infarction in a primary care emergency setting: a cohort study.
Johannessen TR, Atar D, Vallersnes OM, Larstorp ACK, et al · · 2021 · cited 11× · PMID 33627355 · DOI 10.1136/bmjopen-2020-046024 -
Performance of the Novel Observation Group Criteria of the European Society of Cardiology (ESC) 0/1-Hour Algorithm in a Low-Risk Population.
Johannessen TR, Halvorsen S, Atar D, Vallersnes OM. · · 2022 · cited 3× · PMID 35352564 · DOI 10.1161/jaha.121.024927 -
Adequately identifying low-risk chest pain in emergency primary care: evaluating the performance of preHEAR(T) based on two European cohorts.
Johannessen TR, Melessen IMB, Vallersnes OM, Manten A, et al · · 2025 · PMID 40716792 · DOI 10.1136/openhrt-2025-003362
Verify or expand the search:
- PubMed search for NCT02983123
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Oslo University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02983123 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oslo University Hospital
- Last refreshed: 14 March 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02983123.
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