Who is sponsoring NCT05812963?

NCT05812963 is sponsored by Samsung Medical Center.

What drugs are being tested in NCT05812963?

Interventions in NCT05812963: IVUS-guided PCI group, FFR-guided PCI group.

What condition does NCT05812963 study?

NCT05812963 studies ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction.

Is NCT05812963 still recruiting?

NCT05812963 is currently recruiting now. Last updated 24 October 2024.

Last reviewed 2024-10-24 · How we verify

NCT05812963: FRAME-AMI2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

IVUS Versus FFR for Non-infarct Related Artery Lesions in Patients With Multivessel Disease and Acute MI

Recruiting now NA Last updated 24 October 2024

What this trial tests

NA trial testing IVUS-guided PCI group in ST Elevation Myocardial Infarction in 1,400 participants. Currently enrolling.

Timeline

18 September 2023

Primary endpoint
31 December 2028

31 December 2029

Quick facts

Lead sponsor	Samsung Medical Center
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	1,400
Start date	18 September 2023
Primary completion	31 December 2028
Estimated completion	31 December 2029
Sites	2 locations across South Korea

Drugs / interventions tested

IVUS-guided PCI group
FFR-guided PCI group

Conditions studied

ST Elevation Myocardial Infarction — all drugs for ST Elevation Myocardial Infarction →
Non-ST Elevation Myocardial Infarction — all drugs for Non-ST Elevation Myocardial Infarction →

Sponsor

Samsung Medical Center

Who can join

19 and older, any sex, with ST Elevation Myocardial Infarction or Non-ST Elevation Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the study is to compare clinical outcomes between intravascular ultrasound (IVUS)-guided treatment decision versus fractional flow reserve (FFR)-guided treatment decision for non-infarct related artery stenosis in patients with acute myocardial infarction (AMI) and multivessel disease.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Revascularization Strategy in Myocardial Infarction with Multivessel Disease.
Jobs A, Desch S, Freund A, Feistritzer HJ, et al · · 2024 · cited 5× · PMID 38610683 · DOI 10.3390/jcm13071918
Do we need to be fully complete in multivessel acute myocardial infarction?
Smits PC, Paradies V. · · 2025 · cited 1× · PMID 39962950 · DOI 10.4244/eij-e-25-00003
Optimal Timing of Angiography-Guided Complete Revascularization of Non-Culprit Lesions in STEMI Patients with Multivessel Disease.
Sucato V, Madaudo C, Marotta A, Ortello A, et al · · 2024 · PMID 39274282 · DOI 10.3390/jcm13175070

Verify or expand the search:

Other recruiting trials for ST Elevation Myocardial Infarction

Currently open trials in the same condition.

NCT05785897 — STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT · NA · recruiting
NCT06795035 — Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution · recruiting
NCT07058857 — The Effect of Low-Level Tragus Stimulation on Echocardiographic Parameters in Patients With ST-Segment Elevation Myocard · NA · recruiting
NCT06465303 — A Study of RTP-026 to Assess Safety, Tolerability and Efficacy in Patients With ST-Elevation Myocardial Infarction (STEM · Phase 2 · recruiting
NCT06535503 — Clinical Characteristics and Outcomes Among STEMI Patients With Cardiogenic Shock at Abu Dhabi City · recruiting

Other Samsung Medical Center trials

Trials by the same sponsor.

NCT07482865 — Routine Versus Provisional Distal Perfusion Catheter Placement in Patients Undergoing Mechanical Circulatory Support · NA · not yet recruiting
NCT07467213 — Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute M · Phase 4 · not yet recruiting
NCT07530913 — Effectiveness Analysis of a Rehabilitation Exercise Platform for Living Donor Liver Transplantation Patients · NA · enrolling by invitation
NCT07500701 — Salvage Moderate Hypofractionated Versus Ultrahypofractionated Radiotherapy for Biochemical Recurrence After Radical Pro · Phase 3 · recruiting
NCT07409441 — Korea Acute Myocardial Infarction Registry · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05812963 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Samsung Medical Center
Last refreshed: 24 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05812963.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing