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NCT02943161: ALPS
Asthma L-Citrulline Pilot Study
NA trial testing L-Citrulline in Asthma in 41 participants. Completed in 31 March 2019.
31 March 2019
Quick facts
| Lead sponsor | University of Colorado, Denver |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 41 |
| Start date | 5 April 2017 |
| Primary completion | 31 March 2019 |
| Estimated completion | 31 March 2019 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- L-Citrulline (Citrulline) — full drug profile →
Conditions studied
- Asthma — all drugs for Asthma →
Sponsor
University of Colorado, Denver
Who can join
Adults 18 to 70, any sex, with Asthma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will evaluate whether treatment with L-citrulline, which is an amino acid found in some foods, can increase levels of L-arginine and thereby restore the concentration of nitric oxide (NO) in the airways.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Gaps and Future Directions in Clinical Research on Obesity-Related Asthma.
Hudler AC, Díaz IRR, Sharma S, Holguin F. · · 2023 · cited 5× · PMID 37330948 · DOI 10.1007/s41030-023-00230-2 -
Obesity: Next game changer of allergic airway diseases?
Li W, Marx N, Yang Q, Fang D, et al · · 2025 · cited 2× · PMID 40329860 · DOI 10.1002/ctm2.70316
Verify or expand the search:
- PubMed search for NCT02943161
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of L-Citrulline
Trials testing the same drug.
- NCT06025383 — 2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hyper · NA · completed
- NCT05974813 — The Effect of Short-term L-citrulline Supplementation on Blood Pressure and Arterial Stiffness · NA · completed
- NCT06312748 — Novel Approaches for Improving Vascular Function in Veterans With HFpEF · Phase 1 · recruiting
- NCT03952234 — L-Citrulline Dose Finding Safety Study in MELAS · Phase 1 · completed
- NCT04570384 — Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failu · Phase 2 · completed
Other recruiting trials for Asthma
Currently open trials in the same condition.
- NCT07525375 — A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared t · Phase 2 · recruiting
- NCT07536256 — Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being · NA · recruiting
- NCT07556159 — A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice · recruiting
- NCT07282886 — VENTURI (VENTilation Using Respiratory Imaging) · Phase 2 · recruiting
- NCT07433569 — A Study to Investigate How Budesonide and Formoterol Move Through the Body (Pharmacokinetics) When Delivered With Differ · Phase 1 · recruiting
Other University of Colorado, Denver trials
Trials by the same sponsor.
- NCT07292285 — The Surveillance Nonoperative Watch & Wait (SNOWW) Rectal Cancer Trial. · not yet recruiting
- NCT07021937 — Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity · Phase 3 · not yet recruiting
- NCT07453732 — Banana Leaves as a Wound Dressing for Partial Thickness Second Degree Burns in Adult Patients. · NA · not yet recruiting
- NCT07038278 — 5-AminoLevulinic Acid Aided Resection Margins in Sarcoma · EARLY_PHASE1 · not yet recruiting
- NCT07279558 — Cannabidiol and Alcohol Use Disorder Phenotypes · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02943161 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Denver
- Last refreshed: 27 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02943161.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing