NCT02896673

Evaluation of the Diagnostic Performance of Electrical Impedance Tomography to Detect Situations at Risk of Lesions Induced by Conventional Mechanical Ventilation in ARDS

Completed NA Last updated 15 November 2018

What this trial tests

NA trial testing ventilatory conditions and measures with scanner and EIT in Respiratory Distress Syndrome in 3 participants. Completed in 21 January 2015.

Timeline

17 July 2012

Primary endpoint
21 January 2015

21 January 2015

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	3
Start date	17 July 2012
Primary completion	21 January 2015
Estimated completion	21 January 2015
Sites	1 location across France

Drugs / interventions tested

• ventilatory conditions and measures with scanner and EIT

Conditions studied

• Respiratory Distress Syndrome — all drugs for Respiratory Distress Syndrome →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

18 and older, any sex, with Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Acute respiratory distress syndrome remains a serious condition, with a mortality rate of between 30 and 50%. The use of mechanical ventilation with small tidal volumes, and by limiting the plateau pressure in the respiratory tract below 30 cm H2O has been shown to reduce mortality by approximately 10%, probably by reducing pulmonary hyperinflation and pulmonary lesions induced by mechanical ventilation. It is therefore now established that the respirator settings influence patient prognosis. However, around 30% of patients with ARDS ventilated with these settings supposedly protective continue to present signs of pulmonary hyperinflation on tomodensitometry, suggesting an additional reduction in the tidal volume could be required in certain patients. Electrical impedance tomography (EIT) is a new imaging technique that gathers functional pulmonary information at bedside.

This technique also allows a regional analysis, allowing the complexity of the spatial distribution of ARDS pulmonary lesions to be understood. The hypothesis is that EIT is a reliable method to detect at-risk situations of lesions induced by mechanical ventilation among patients with ARDS.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.