NCT02868021 (BFR) is a NA clinical trial of Strength testing in Osteoarthritis, Knee, sponsored by University of Florida.

Who is sponsoring NCT02868021?

NCT02868021 is sponsored by University of Florida.

What drugs are being tested in NCT02868021?

Interventions in NCT02868021: Strength testing, Short Physical Performance Battery (SPPB), Six-minute walk (SMW), Numerical pain scale, Self-assessed function, Muscle biopsies, Determination of 1 Repetition Maximum (1-RM), Blood flow restriction exercise, Borg CR10 scale.

What condition does NCT02868021 study?

NCT02868021 studies Osteoarthritis, Knee.

Is NCT02868021 still recruiting?

NCT02868021 is currently completed. Last updated 24 July 2019.

Last reviewed 2019-07-24 · How we verify

NCT02868021: BFR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Blood Flow Restriction Exercise Study

Completed NA Last updated 24 July 2019

What this trial tests

NA trial testing Strength testing in Osteoarthritis, Knee in 12 participants. Completed in 1 August 2018.

Timeline

12 December 2016

Primary endpoint
1 August 2018

1 August 2018

Quick facts

Lead sponsor	University of Florida
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	health services research
Enrollment	12
Start date	12 December 2016
Primary completion	1 August 2018
Estimated completion	1 August 2018
Sites	1 location across United States

Drugs / interventions tested

Strength testing
Short Physical Performance Battery (SPPB)
Six-minute walk (SMW)
Numerical pain scale
Self-assessed function
Muscle biopsies — full drug profile →
Determination of 1 Repetition Maximum (1-RM)
Blood flow restriction exercise
Borg CR10 scale

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

University of Florida

Who can join

Adults 55 to 80, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This pilot study will investigate the effects of blood flow restriction (BFR) exercise for up to 4-6 weeks prior to total knee arthroplasty (TKA) surgery in older patients to measure clinical outcomes such as strength, lower extremity function, and pain.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The autophagy-senescence axis as a threshold model of aging and therapeutic targeting.
Bahar ME, Hwang JS, Lai TH, Akter KM, et al · · 2026 · cited 2× · PMID 41690118 · DOI 10.1016/j.redox.2026.104079

Verify or expand the search:

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other University of Florida trials

Trials by the same sponsor.

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NCT07507214 — Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athl · Phase 2, PHASE3 · not yet recruiting
NCT07492316 — RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) · Phase 1 · not yet recruiting
NCT06670794 — Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Dri · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02868021 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Florida
Last refreshed: 24 July 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02868021.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing