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NCT02862977
Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment
Phase 3 trial testing ketoprofen and cyclobenzaprine association with caffeine in Musculoskeletal Pain in 414 participants. Completed in 20 December 2019.
5 June 2019
Quick facts
| Lead sponsor | EMS |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 414 |
| Start date | 10 November 2017 |
| Primary completion | 5 June 2019 |
| Estimated completion | 20 December 2019 |
| Sites | 6 locations across Brazil |
Drugs / interventions tested
- ketoprofen and cyclobenzaprine association with caffeine — full drug profile →
- Cyclobenzaprine with caffeine — full drug profile →
Conditions studied
- Musculoskeletal Pain — all drugs for Musculoskeletal Pain →
Sponsor
EMS — full company profile →
Who can join
Adults 18 to 65, any sex, with Musculoskeletal Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to evaluate the safety and efficacy of an association with one anti-inflammatory and one muscle relaxant plus caffeine compared to one anti-inflammatory plus caffeine in the treatment of osteomuscular pain in adults.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.
Jones P, Lamdin R, Dalziel SR. · · 2020 · cited 17× · PMID 32797734 · DOI 10.1002/14651858.cd007789.pub3
Verify or expand the search:
- PubMed search for NCT02862977
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other EMS trials
Trials by the same sponsor.
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- NCT05800392 — Efficacy and Safety of DEC103 in Pain Control Associated to Intrauterine Device (IUD) Insertion · Phase 4 · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02862977 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by EMS
- Last refreshed: 2 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02862977.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing