NCT02846675 is a Phase 1, PHASE2 clinical trial of autologous SVF in Osteoarthritis, sponsored by Shanghai East Hospital.

Who is sponsoring NCT02846675?

NCT02846675 is sponsored by Shanghai East Hospital.

What drugs are being tested in NCT02846675?

Interventions in NCT02846675: autologous SVF, Placebo.

What condition does NCT02846675 study?

NCT02846675 studies Osteoarthritis.

Is NCT02846675 still recruiting?

NCT02846675 is currently completed. Last updated 11 September 2018.

Last reviewed 2018-09-11 · How we verify

NCT02846675

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Safety and Efficacy of Autologous SVF Cells in Treating Patients With Osteoarthritis

Completed Phase 1, PHASE2 Last updated 11 September 2018

What this trial tests

Phase 1, PHASE2 trial testing autologous SVF in Osteoarthritis in 50 participants. Completed in 31 January 2018.

Timeline

1 November 2014

Primary endpoint
31 July 2017

31 January 2018

Quick facts

Lead sponsor	Shanghai East Hospital
Phase	Phase 1, PHASE2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	50
Start date	1 November 2014
Primary completion	31 July 2017
Estimated completion	31 January 2018
Sites	1 location across China

Drugs / interventions tested

autologous SVF — full drug profile →
Placebo

Conditions studied

Osteoarthritis — all drugs for Osteoarthritis →

Sponsor

Shanghai East Hospital

Who can join

Adults 18 to 70, any sex, with Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

it's a self-control, double blind study of autologous adipose-derived stromal vascular fraction (SVF) to treat 50 osteoarthritic knees of grade II or III (K-L scale) under IRB-approved protocol in a feasibility and safety study.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments.
Vrouwe JPM, Burggraaf J, Kloppenburg M, Stuurman FE. · · 2021 · cited 16× · PMID 36474768 · DOI 10.1016/j.ocarto.2021.100212
Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis.
Tang Q, Zhao XS, Guo A, Cui RT, et al · · 2022 · cited 8× · PMID 36337155 · DOI 10.4252/wjsc.v14.i10.744

Verify or expand the search:

Other recruiting trials for Osteoarthritis

Currently open trials in the same condition.

NCT07404891 — Clinical Trial on the Efficacy and Safety of ALT001 in Osteoarthritis · NA · recruiting
NCT07118501 — A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System · recruiting
NCT06631638 — EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN)) · NA · recruiting
NCT07198750 — "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis" · NA · recruiting
NCT07006714 — Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) · Phase 4 · active not recruiting

Other Shanghai East Hospital trials

Trials by the same sponsor.

NCT07519161 — Pharmacological Intervention to Prevent NOAF After TAVR · NA · not yet recruiting
NCT07516223 — MRI-Assisted Guidance for Non-Essential Tissue Sampling · NA · not yet recruiting
NCT07279259 — Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management · Phase 2 · recruiting
NCT07294495 — Effect of Henagliflozin on Myocardial Fibrosis in Non-Obstructive HCM: A Randomized, Double-Blind, Placebo-Controlled Tr · NA · not yet recruiting
NCT07290816 — Effect of Non-invasive Neuromodulation on the Quality of Intestinal Cleansing · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02846675 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai East Hospital
Last refreshed: 11 September 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02846675.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing