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NCT02766556
The Effect of Dexamedetomidine for Interscalene Brachial Plexus Block on Plasma Cortisol and IL-6 After Rotator Cuff Repair: a Prospective Randomized Study
NA trial testing dexmedetomidine in Pain in 50 participants. Completed in 1 January 2016.
1 August 2015
Quick facts
| Lead sponsor | Chuncheon Sacred Heart Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 50 |
| Start date | 1 August 2014 |
| Primary completion | 1 August 2015 |
| Estimated completion | 1 January 2016 |
Drugs / interventions tested
- dexmedetomidine (dexmedetomidine) — full drug profile →
- ISB
- Ropivacaine (ROPIVACAINE) — full drug profile →
Conditions studied
- Pain — all drugs for Pain →
Sponsor
Chuncheon Sacred Heart Hospital
Who can join
20 and older, any sex, with Pain. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
change of five biomarkers (IL-6 in pg/ml, cortisol in ng/ml, IL-8 in pg/ml, IL-1beta in pg/ml, substance p in pg/ml) level due to pain after shoulder surgery.
Time frame: change from preoperation(baseline) IL-6, cortisol, IL-8, IL-1beta, and substance p level 1, 6, 12, 24, 48 hours after surgery due to postoperative pain
Sponsor's own description
The present study was designed to test the hypothesis that dexmedetomidine added to ropivacaine for interscalene brachial plexus blocks for elective shoulder surgery would enhance the duration and effect of analgesia when compared with ropivacaine alone, and their influence on serum IL-6, cortisol, IL-1beta, IL-8, and substance p.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Dexmedetomidine combined with interscalene brachial plexus block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair.
Hwang JT, Jang JS, Lee JJ, Song DK, et al · · 2020 · cited 19× · PMID 31773201 · DOI 10.1007/s00167-019-05799-3
Verify or expand the search:
- PubMed search for NCT02766556
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of dexmedetomidine
Trials testing the same drug.
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- NCT06702488 — Dexmedetomidine and Magnesium Sulfate in the Reduction Cognitive Dysfunction in Geriatrics · Phase 1 · recruiting
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- NCT07510217 — ERAS Approach for Post-Craniotomy Headache and Psychological Recovery · Phase 2 · completed
- NCT06498700 — Intraoperative Subanesthetic Ketamine Versus Dexmedetomidine Infusion for Prevention of Post-traumatic Stress Disorder A · NA · enrolling by invitation
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Other Chuncheon Sacred Heart Hospital trials
Trials by the same sponsor.
- NCT07039955 — Effect of Daily Chlorhexidine Bathing and Antibiotic/PPI Stewardship on Prevention of CPE Transmission and Infection · NA · enrolling by invitation
- NCT07001228 — Scapular Dyskinesis With Impingement Syndrome · NA · not yet recruiting
- NCT06878391 — ISB With SSNB & ANB · NA · recruiting
- NCT06055491 — Vitamin D3 Combined With Strengthening Exercise for Lateral Epicondylitis of Elbow · NA · unknown
- NCT06055478 — Effect of Suprascapular Nerve Block and Axillary Nerve Block After Arthroscopic Rotator Cuff Repair · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02766556 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chuncheon Sacred Heart Hospital
- Last refreshed: 5 May 2016
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02766556.
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