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NCT02750163
Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient
trial testing paracetamol in Sepsis and Septic Shock in 50 participants. Completed in 5 June 2019.
5 June 2019
Quick facts
| Lead sponsor | Università Politecnica delle Marche |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 5 July 2017 |
| Primary completion | 5 June 2019 |
| Estimated completion | 5 June 2019 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- paracetamol (Paracetamol) — full drug profile →
Conditions studied
- Sepsis and Septic Shock — all drugs for Sepsis and Septic Shock →
Sponsor
Università Politecnica delle Marche — full company profile →
Who can join
18 and older, any sex, with Sepsis and Septic Shock. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to evaluate the effect of Acetaminophen on the main parameters of microcirculation, on the plasmatic levels of free hemoglobin/oxidative stress markers and on the expression of PD1/Pd-L1, in pyrexial septic patient.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study.
Domizi R, Damiani E, Carsetti A, Graciotti L, et al · · 2024 · cited 3× · PMID 38340203 · DOI 10.1186/s13613-024-01251-z -
Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.
Scorcella C, Domizi R, Amoroso S, Carsetti A, et al · · 2023 · cited 3× · PMID 36797680 · DOI 10.1186/s12871-023-02018-y -
Pharmacogenetics in critical care: the expression of rs776746 polymorphism and acetaminophen response in sepsis and septic shock
Scorcella C, Domizi R, Amoroso S, Carsetti A, et al · · 2022 · DOI 10.21203/rs.3.rs-1971505/v1
Verify or expand the search:
- PubMed search for NCT02750163
- Europe PMC full search
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Related trials
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Trials testing the same drug.
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Other recruiting trials for Sepsis and Septic Shock
Currently open trials in the same condition.
- NCT06809868 — Role of Transposable Elements in Septic Immune Aging · recruiting
- NCT06680180 — Fibrinolysis Resistance in Infection and Trauma · recruiting
Other Università Politecnica delle Marche trials
Trials by the same sponsor.
- NCT07189520 — 1. SAFE-AI ONCO-TRACK: Multimodal GenAI for Early Detection of Minimal Residual Disease and Recurrence in Gastrointestin · not yet recruiting
- NCT07404475 — Microcirculation and Coagulopathy in Sepsis · completed
- NCT06272448 — teleRehabilitation for pAtients With ParkInson's Disease at Any mOment · NA · completed
- NCT05267834 — Adenocarcinoma of the Uterine Cervix and HPV · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02750163 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Università Politecnica delle Marche
- Last refreshed: 18 July 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02750163.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing