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NCT02719210
High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure
NA trial testing High Volume Plasma Exchange in Acute Liver Failure in 75 participants. Completed in 30 November 2018.
30 November 2018
Quick facts
| Lead sponsor | Institute of Liver and Biliary Sciences, India |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 75 |
| Start date | 1 January 2016 |
| Primary completion | 30 November 2018 |
| Estimated completion | 30 November 2018 |
| Sites | 1 location across India |
Drugs / interventions tested
- High Volume Plasma Exchange
- Hypertonic 3% saline
- Mannitol (Mannitol) — full drug profile →
- Elective positive pressure ventilation
Conditions studied
- Acute Liver Failure — all drugs for Acute Liver Failure →
Sponsor
Institute of Liver and Biliary Sciences, India
Who can join
Adults 1 to 18, any sex, with Acute Liver Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
All the children with acute liver failure who are candidates for transplant but have constraints for transplant will be randomized either to receive standard medical therapy or high volume plasma exchange along with standard medical therapy with the aim to assess the effect of high volume plasma exchange on transplant free survival.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT02719210
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High Volume Plasma Exchange
Trials testing the same drug.
- NCT04015570 — Efficacy and Safety of Plasma Exchange Compared to Standard Medical Therapy in Patients With Severe Drug Induced Liver I · NA · unknown
Other recruiting trials for Acute Liver Failure
Currently open trials in the same condition.
- NCT06831643 — Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure · NA · recruiting
- NCT06872372 — Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure · NA · active not recruiting
- NCT07329036 — ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of · NA · recruiting
- NCT05689645 — F573 for Injection for the Treatment of Liver Injury/Failure · Phase 2 · recruiting
- NCT05413083 — Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis · active not recruiting
Other Institute of Liver and Biliary Sciences, India trials
Trials by the same sponsor.
- NCT07480005 — To Revisit the Yield of Staging Laparoscopy in Hepatopancreatobiliary Malignancies · recruiting
- NCT07480057 — Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry · recruiting
- NCT07465471 — Carvedilol and Midodrine Versus Carvedilol Alone in Preventing Early Rebleed in Patients With Cirrhosis. · NA · not yet recruiting
- NCT07433881 — Serosurvey of HAV Immunity and Single-dose Vaccine Immunogenicity Among Patients With Cirrhosis · not yet recruiting
- NCT07422948 — Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02719210 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Institute of Liver and Biliary Sciences, India
- Last refreshed: 6 December 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02719210.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing