NCT02714465 (GKSHBO) is a NA clinical trial of hyperbaric oxygen therapy in Cerebral Necrosis, sponsored by Niguarda Hospital.

Who is sponsoring NCT02714465?

NCT02714465 is sponsored by Niguarda Hospital.

What drugs are being tested in NCT02714465?

Interventions in NCT02714465: hyperbaric oxygen therapy.

What condition does NCT02714465 study?

NCT02714465 studies Cerebral Necrosis.

Is NCT02714465 still recruiting?

NCT02714465 is currently completed. Last updated 22 March 2023.

Last reviewed 2023-03-22 · How we verify

NCT02714465: GKSHBO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Adverse Radiation Effects After Gamma Knife Radio Surgery and Hyperbaric Oxygen Therapy

Completed NA Last updated 22 March 2023

What this trial tests

NA trial testing hyperbaric oxygen therapy in Cerebral Necrosis in 65 participants. Completed in 1 March 2023.

Timeline

1 March 2016

Primary endpoint
1 December 2022

1 March 2023

Quick facts

Lead sponsor	Niguarda Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	65
Start date	1 March 2016
Primary completion	1 December 2022
Estimated completion	1 March 2023
Sites	1 location across Italy

Drugs / interventions tested

hyperbaric oxygen therapy — full drug profile →

Conditions studied

Cerebral Necrosis — all drugs for Cerebral Necrosis →

Sponsor

Niguarda Hospital

Who can join

Adults 10 to 75, any sex, with Cerebral Necrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Evaluation of clinical improvement and the reduction of edema lesion documented by magnetic resonance imaging (MRI) in patients with cerebral radiation necrosis post gamma knife surgery (GKS) by treatment with hyperbaric oxygen therapy (HBO)

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Hyperbaric oxygen therapy for late radiation tissue injury.
Bennett MH, Feldmeier J, Hampson NB, Smee R, et al · · 2016 · cited 49× · PMID 27123955 · DOI 10.1002/14651858.cd005005.pub4
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD. · · 2018 · cited 32× · PMID 29987845 · DOI 10.1002/14651858.cd011492.pub2
Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, et al · · 2023 · cited 25× · PMID 37585677 · DOI 10.1002/14651858.cd005005.pub5

Verify or expand the search:

Other trials of hyperbaric oxygen therapy

Trials testing the same drug.

NCT07311109 — A Prospective, Single-center, Randomized Controlled Clinical Study Evaluating the Efficacy and Safety of Hyperbaric Oxyg · NA · not yet recruiting
NCT06493851 — The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR) · NA · recruiting
NCT07423273 — Hyperbaric Oxygen Therapy for Persistent Post Stroke Depression · NA · recruiting
NCT05646875 — A Comprehensive Evaluation of Hyperbaric Oxygen Therapy in Resuscitation Medicine - a Pilot Study (HOT-RESUS 1 Trial) · NA · completed
NCT05715801 — Hyperbaric Oxygen Therapy Improves Brain Function in Patients With Cognitive Decline After COVID-19 Infection. · NA · unknown

Other Niguarda Hospital trials

Trials by the same sponsor.

NCT05105399 — Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures · NA · not yet recruiting
NCT07153224 — The MICROSCOPE Project · not yet recruiting
NCT04763993 — Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study · NA · not yet recruiting
NCT07432347 — Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches · recruiting
NCT07234409 — Clinical Trial Addressing the Best Surgical Approach for Partial Nephrectomy With Single Port Robotic System in the Mana · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02714465 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Niguarda Hospital
Last refreshed: 22 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02714465.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing