NCT02686021 (NovIbu) is a Phase 4 clinical trial of Metamizole and Ibuprofen in Pain, Postoperative, sponsored by University Hospital, Basel, Switzerland.

Who is sponsoring NCT02686021?

NCT02686021 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT02686021?

Interventions in NCT02686021: Metamizole and Ibuprofen, Metamizole and Placebo, Ibuprofen and Placebo.

What condition does NCT02686021 study?

NCT02686021 studies Pain, Postoperative.

Is NCT02686021 still recruiting?

NCT02686021 is currently completed. Last updated 4 May 2021.

Last reviewed 2021-05-04 · How we verify

NCT02686021: NovIbu

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction

Completed Phase 4 Last updated 4 May 2021

What this trial tests

Phase 4 trial testing Metamizole and Ibuprofen in Pain, Postoperative in 36 participants. Completed in 28 April 2021.

Timeline

15 February 2016

Primary endpoint
28 April 2021

28 April 2021

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	36
Start date	15 February 2016
Primary completion	28 April 2021
Estimated completion	28 April 2021
Sites	1 location across Switzerland

Drugs / interventions tested

Metamizole and Ibuprofen — full drug profile →
Metamizole and Placebo — full drug profile →
Ibuprofen and Placebo — full drug profile →

Conditions studied

Pain, Postoperative — all drugs for Pain, Postoperative →

Sponsor

University Hospital, Basel, Switzerland

Who can join

Adults 18 to 60, any sex, with Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Postoperative pain is common and particularly outpatients may experience unsatisfactory pain relief. This randomized, double-blind, crossover study of postoperative pain in outpatients undergoing split-mouth, third lower molar extraction aims to examine whether or not the combination of metamizole and ibuprofen is superior to either drug alone.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Parenteral Ready-to-Use Fixed-Dose Combinations Including NSAIDs with Paracetamol or Metamizole for Multimodal Analgesia-Approved Products and Challenges.
Silva F, Costa G, Veiga F, Cardoso C, et al · · 2023 · cited 6× · PMID 37630999 · DOI 10.3390/ph16081084

Verify or expand the search:

Other recruiting trials for Pain, Postoperative

Currently open trials in the same condition.

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Other University Hospital, Basel, Switzerland trials

Trials by the same sponsor.

NCT07444788 — Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants · Phase 1 · recruiting
NCT07494214 — Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants · Phase 1 · recruiting
NCT07419048 — Artificial Intelligence or Human Hand? Evaluating Inferior Vena Cava Imaging for Hydration Status · recruiting
NCT06978777 — Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity · NA · recruiting
NCT07273630 — Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02686021 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 4 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02686021.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing