NCT02681627 (SiM) is a NA clinical trial of Endometrial scratch in Recurrent Miscarriage, sponsored by University Hospitals Coventry and Warwickshire NHS Trust.

Who is sponsoring NCT02681627?

NCT02681627 is sponsored by University Hospitals Coventry and Warwickshire NHS Trust.

What drugs are being tested in NCT02681627?

Interventions in NCT02681627: Endometrial scratch, Touching the cervix.

What condition does NCT02681627 study?

NCT02681627 studies Recurrent Miscarriage.

Is NCT02681627 still recruiting?

NCT02681627 is currently completed. Last updated 29 January 2019.

Last reviewed 2019-01-29 · How we verify

NCT02681627: SiM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sim (Scratch in Miscarriage) Study

Completed NA Last updated 29 January 2019

What this trial tests

NA trial testing Endometrial scratch in Recurrent Miscarriage in 109 participants. Completed in 1 September 2017.

Timeline

30 November 2015

Primary endpoint
26 June 2017

1 September 2017

Quick facts

Lead sponsor	University Hospitals Coventry and Warwickshire NHS Trust
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	109
Start date	30 November 2015
Primary completion	26 June 2017
Estimated completion	1 September 2017
Sites	1 location across United Kingdom

Drugs / interventions tested

Endometrial scratch
Touching the cervix

Conditions studied

Recurrent Miscarriage — all drugs for Recurrent Miscarriage →

Sponsor

University Hospitals Coventry and Warwickshire NHS Trust

Who can join

Adults 18 to 40, female only, with Recurrent Miscarriage. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

There is increasing amount of evidence which suggests that miscarriage is related to a primary endometrial problem. Recent cochrane meta-analysis (March 2015) has proven that endometrial scratch improves live birth in women who underwent IVF. The aim of the study is to find out if scratch of the endometrium prevents recurrent miscarriage.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination.
Bui BN, Lensen SF, Gibreel A, Martins WP, et al · · 2021 · cited 6× · PMID 33734431 · DOI 10.1002/14651858.cd011424.pub3
Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination.
Bui BN, Lensen SF, Gibreel A, Martins WP, et al · · 2022 · cited 3× · PMID 36278845 · DOI 10.1002/14651858.cd011424.pub4
The value of endometrial scratch injury in infertile women trying to conceive through non-in vitro fertilization cycles: A systematic review and meta-analysis.
El-Goly NAM, Maged AM, Bassiouny N, Mahmoud SI, et al · · 2025 · PMID 41354031 · DOI 10.5653/cerm.2024.07612

Verify or expand the search:

Other trials of Endometrial scratch

Trials testing the same drug.

NCT03163862 — G-CSF Administration in IVF in a Preferable Preceptive Endometrium Score · Phase 2, PHASE3 · unknown
NCT03108157 — Endometrial Scratch Effect on Pregnancy Rates in Patients Undergoing Egg-donation IVF · NA · completed

Other recruiting trials for Recurrent Miscarriage

Currently open trials in the same condition.

NCT06826365 — Immune Cell Populations in the Endometrium · recruiting
NCT06356792 — Obstetrics , Prenatal Outcomes in Recurrent Miscarriage · recruiting
NCT06163092 — Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage · recruiting
NCT05725512 — Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages · Phase 4 · recruiting
NCT03902912 — Effect of Prednisolone Treatment on Uterine Natural Killer Cells · Phase 3 · recruiting

Other University Hospitals Coventry and Warwickshire NHS Trust trials

Trials by the same sponsor.

NCT07353255 — Fibrescope vs Videolaryngoscope for Nasotracheal Intubation · NA · not yet recruiting
NCT06937983 — Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Stru · NA · recruiting
NCT06483308 — Shortened High-dose Palliative Radiotherapy for Lung Cancer · NA · active not recruiting
NCT07014033 — Single-use Versus Multiple-use Endoscopes in Gastroenterology · recruiting
NCT06676943 — Investigating the Diagnostic Performance of High-resolution Specimen PET-CT in Determining Margin Status in Cancer Resec · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02681627 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospitals Coventry and Warwickshire NHS Trust
Last refreshed: 29 January 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02681627.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing