NCT02660411 is a NA clinical trial of Sevoflurane in Aged, sponsored by Peking University First Hospital.

Who is sponsoring NCT02660411?

NCT02660411 is sponsored by Peking University First Hospital.

What drugs are being tested in NCT02660411?

Interventions in NCT02660411: Sevoflurane, Propofol.

What condition does NCT02660411 study?

NCT02660411 studies Aged, Neoplasms, Surgical Procedure, Operative, Anesthesia, Inhalation, Anesthesia, Intravenous, Survival.

Is NCT02660411 still recruiting?

NCT02660411 is currently completed. Last updated 4 March 2022.

Last reviewed 2022-03-04 · How we verify

NCT02660411

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Anesthesia Maintenance Methods on Long-term Survival

Completed NA Last updated 4 March 2022

What this trial tests

NA trial testing Sevoflurane in Aged in 1,228 participants. Completed in 30 September 2020.

Timeline

1 April 2015

Primary endpoint
29 September 2017

30 September 2020

Quick facts

Lead sponsor	Peking University First Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	1,228
Start date	1 April 2015
Primary completion	29 September 2017
Estimated completion	30 September 2020
Sites	17 locations across China

Drugs / interventions tested

Sevoflurane — full drug profile →
Propofol (Propofol) — full drug profile →

Conditions studied

Aged — all drugs for Aged →
Neoplasms — all drugs for Neoplasms →
Surgical Procedure, Operative — all drugs for Surgical Procedure, Operative →
Anesthesia, Inhalation — all drugs for Anesthesia, Inhalation →

Sponsor

Peking University First Hospital

Who can join

Adults 65 to 90, any sex, with Aged or Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Surgery is one of the major treatment methods for patients with malignant tumor. And, alone with the ageing process, more and more elderly patients undergo surgery for malignant tumor. Evidence emerges that choice of anesthetics, i.e., either inhalational or intravenous anesthetics, may influence the outcome of elderly patients undergoing cancer surgery. From the point of view of immune function after surgery and invasiveness of malignant tumor cells, propofol intravenous anesthesia may be superior to inhalational anesthesia. However, the clinical significance of these effects remains unclear. Retrospective studies indicated that use of propofol intravenous anesthesia was associated higher long-term survival rate. Prospective studies exploring the effect of anesthetic choice on long-term survival in cancer surgery patients are urgently needed.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial.
Cao SJ, Zhang Y, Zhang YX, Zhao W, et al · · 2023 · cited 32× · PMID 37474242 · DOI 10.1016/j.bja.2023.01.023
Long-term prognosis after cancer surgery with inhalational anesthesia and total intravenous anesthesia: a systematic review and meta-analysis.
Jin Z, Li R, Liu J, Lin J. · · 2019 · cited 31× · PMID 31333811
Anesthetic Strategies in Oncological Surgery: Not Only a Simple Sleep, but Also Impact on Immunosuppression and Cancer Recurrence.
Longhini F, Bruni A, Garofalo E, De Sarro R, et al · · 2020 · cited 26× · PMID 32104075 · DOI 10.2147/cmar.s237224
Anesthetics or anesthetic techniques and cancer surgical outcomes: a possible link.
Alam A, Rampes S, Patel S, Hana Z, et al · · 2021 · cited 22× · PMID 33596628 · DOI 10.4097/kja.20679
Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial.
Zhang Y, Li HJ, Wang DX, Jia HQ, et al · · 2017 · cited 16× · PMID 29187413 · DOI 10.1136/bmjopen-2017-018607
The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: a pilot randomized controlled trial.
Efremov SM, Kozireva VS, Moroz GB, Abubakirov MN, et al · · 2020 · cited 6× · PMID 32098012 · DOI 10.4097/kja.19461
General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description.
Bennett-Guerrero E, Romeiser JL, DeMaria S, Nadler JW, et al · · 2023 · cited 3× · PMID 36631831 · DOI 10.1186/s13741-022-00290-z
Harnessing interventions during the immediate perioperative period to improve the long-term survival of patients following radical gastrectomy.
Liu LB, Li J, Lai JX, Shi S. · · 2023 · cited 2× · PMID 37206066 · DOI 10.4240/wjgs.v15.i4.520

Verify or expand the search:

Other trials of Sevoflurane

Trials testing the same drug.

NCT07525648 — Comparison of the Effects of Sevoflurane and Desflurane on Optic Nerve Sheath Diameter During Laparoscopic Surgery · NA · recruiting
NCT07511634 — Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Cont · NA · not yet recruiting
NCT07440758 — Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy · NA · not yet recruiting
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NCT07152912 — Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy · NA · recruiting

Other recruiting trials for Aged

Currently open trials in the same condition.

NCT07481851 — Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients · recruiting
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NCT06929351 — Effect of Otago Exercise Program in Comparison With Dual Task Training on Balance and Postural Control in Elderly Popula · NA · active not recruiting

Other Peking University First Hospital trials

Trials by the same sponsor.

NCT07498907 — Disitamab Vedotin Plus Radiotherapy for Adjuvant Treatment of HER2-Expressing Cisplatin-Ineligible Upper Tract Urothelia · Phase 2 · not yet recruiting
NCT07517276 — TUDCA in High-Risk Lactating Mothers Identified by Early Postpartum Milk Hydrophobicity Index · Phase 2 · not yet recruiting
NCT07504939 — Multimodal Kidney-Sparing Strategy for High-Risk Upper Tract Urothelial Carcinoma · not yet recruiting
NCT07464119 — A Clinical Study of iPSC-Derived Islet Cells for Diabetes Mellitus Therapy · NA · not yet recruiting
NCT07460843 — Comparison of TB+PB and TB+6SB for Prostate Cancer Diagnosis · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02660411 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Peking University First Hospital
Last refreshed: 4 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02660411.

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