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NCT02599272: PSP
Effects of Mixed Spices on Cardiometabolic Function - the PolySPice (PSP) Study
NA trial testing Rice with tomatoes and peeled aubergine (no spice) in Cardiometabolic Risk in 33 participants. Completed in 26 March 2018.
26 March 2018
Quick facts
| Lead sponsor | Singapore Institute of Food and Biotechnology Innovation |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | other |
| Enrollment | 33 |
| Start date | 7 October 2015 |
| Primary completion | 26 March 2018 |
| Estimated completion | 26 March 2018 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- Rice with tomatoes and peeled aubergine (no spice)
- Rice with vegetables and low spice
- Rice with vegetables and high spice
Conditions studied
- Cardiometabolic Risk — all drugs for Cardiometabolic Risk →
Sponsor
Singapore Institute of Food and Biotechnology Innovation
Who can join
Adults 21 to 40, male only, with Cardiometabolic Risk. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study will investigate whether having mixed spices rich in polyphenols can improve postprandial cardiometabolic response in healthy Chinese men.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
A single serving of mixed spices alters gut microflora composition: a dose-response randomised trial.
Khine WWT, Haldar S, De Loi S, Lee YK. · · 2021 · cited 8× · PMID 34050197 · DOI 10.1038/s41598-021-90453-7 -
Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study.
Haldar S, Lee SH, Tan JJ, Chia SC, et al · · 2018 · cited 7× · PMID 30037045 · DOI 10.3390/nu10070934 -
Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake - A Randomized Crossover Trial.
Haldar S, Pakkiri LS, Lim J, Chia SC, et al · · 2018 · cited 3× · PMID 30687117 · DOI 10.3389/fphys.2018.01899 -
Effects of Two Doses of Curry Prepared with Mixed Spices on Postprandial Ghrelin and Subjective Appetite Responses-A Randomized Controlled Crossover Trial.
Haldar S, Lim J, Chia SC, Ponnalagu S, et al · · 2018 · cited 2× · PMID 29587471 · DOI 10.3390/foods7040047
Verify or expand the search:
- PubMed search for NCT02599272
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Singapore Institute of Food and Biotechnology Innovation trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02599272 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Singapore Institute of Food and Biotechnology Innovation
- Last refreshed: 11 October 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02599272.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing