NCT02567448

Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA

Terminated NA Last updated 7 May 2020

What this trial tests

NA trial testing Sleep and pulmonary physiologic measurements in Obstructive Sleep Apnea in 24 participants. Terminated before completion.

Timeline

1 July 2015

Primary endpoint
11 August 2016

11 August 2016

Quick facts

Lead sponsor	University of California, San Diego
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	24
Start date	1 July 2015
Primary completion	11 August 2016
Estimated completion	11 August 2016
Sites	1 location across United States

Drugs / interventions tested

• Sleep and pulmonary physiologic measurements

Conditions studied

• Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →

Sponsor

University of California, San Diego

Who can join

Adults 40 to 70, any sex, with Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of study is to evaluate the physiologic effects of pulmonary tissue/structural changes associated with COPD and upper airway inflammation on upper airway collapsibility. Upper airway collapsibility is closely associated with development of obstructive sleep apnea (OSA), which is a common disease characterized by repetitive collapse of upper airway during sleep, leading to hypoxemia and arousal. OSA has important neurocognitive and cardiovascular consequences, especially in patients with COPD.

Participants in this research study will undergo two overnight sleep studies (PSGs), pulmonary function test, and CT scan of the upper airway and chest. The first sleep study will evaluate the sleep breathing disorder and the second sleep study will measure the upper airway collapsibility, called critical closing pressure (Pcrit). Pcrit is measured by a modified continuous positive airway pressure (CPAP) machine which can provide a wide range of pressures between 20 and -20 cmH2O in order to modify upper airway pressure.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.