NCT02566278

Determination of Upper Airway Collapsibility During Routine CPAP Titration

Terminated NA Last updated 10 July 2019

What this trial tests

NA trial testing Upper airway collapsibility (Pcrit) in Obstructive Sleep Apnea in 20 participants. Terminated before completion.

Timeline

20 October 2015

Primary endpoint
25 July 2016

25 July 2016

Quick facts

Lead sponsor	University of California, San Diego
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	20
Start date	20 October 2015
Primary completion	25 July 2016
Estimated completion	25 July 2016
Sites	1 location across United States

Drugs / interventions tested

• Upper airway collapsibility (Pcrit)

Conditions studied

• Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →

Sponsor

University of California, San Diego

Who can join

Adults 18 to 79, any sex, with Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators hypothesis is that upper airway collapsibility (Pcrit) in patients with obstructive sleep apnea (OSA) can be measured using equipment found in the clinical sleep laboratory and these Pcrit measurements obtained using clinical sleep laboratory equipment is comparable to those obtained using research equipment. OSA is a common disease characterized by repetitive collapse of the upper airway during sleep, leading to hypoxemia and arousals, and which has important neurocognitive and cardiovascular consequences. The single most important factor in the development of OSA is upper airway collapsibility: those with a more collapsible upper airway tend to have OSA while those with a stiffer upper airway do not. The gold standard treatment for OSA is continuous positive airway pressure (CPAP), which acts by stenting open the collapsible airway. Upper airway collapsibility can be measured during sleep by changing the CPAP level and assessing the change in inspiratory flow through the upper airway. Although technically feasible, these measurements are typically only undertaken in research laboratories with specialized equipment. The purpose of this study is to measure upper airway collapsibility using clinically available (i.e. equipment found in a clinical sleep laboratory) equipment only. If successful, upper airway collapsibility could be routinely measured in clinical practice, which could help inform treatment decisions and help individualize therapy for OSA.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.