Cognitive Rehab and Exposure Treatment for Hoarding
CompletedNAResults postedLast updated 19 September 2024
What this trial tests
NA trial testing Cognitive Rehabilitation and Exposure/Sorting Treatment (CREST) in Hoarding Disorder in 115 participants. Completed in 1 February 2023.
Adults 18 to 85, any sex, with Hoarding Disorder. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Saving Inventory RevisedPrimary· Baseline to 6 month-follow-up (12 months total)
Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R)56, a 23-item self-report measure used to assess common hoarding symptoms. Subscales include clutter, acquisition, and difficulty discarding. The SI-R has demonstrated good internal consistency, divergent validity, concurrent validity, and test-retest reliability in clinical samples with hoarding. The total score will be used for analyses. Total of 23 items divided into 3 subscales, each item Likert scale ranges from 0-4 (0= not at all, 4= extreme), Clutter Subscale (9 items): scores greater
Baseline SI-R:
Group
Value
95% CI
CREST
59.9
± 15.8
Exposure Therapy
55.3
± 14.8
Baseline SI-R: Clutter Subcategory
Group
Value
95% CI
CREST
25.2
± 7.7
Exposure Therapy
23.0
± 8.2
Baseline SI-R: Acquisition Subcategory
Group
Value
95% CI
CREST
16.6
± 5.5
Exposure Therapy
14.4
± 5.4
Baseline SI-R: Discarding Subcategory
Group
Value
95% CI
CREST
18.1
± 5.5
Exposure Therapy
17.9
± 5.1
Timepoint 1 (S7) SI-R
Group
Value
95% CI
CREST
51.6
± 16.8
Exposure Therapy
50.5
± 16.4
Timepoint 1 (S7) SI-R: Clutter Subcategory
Group
Value
95% CI
CREST
22.6
± 8.4
Exposure Therapy
21.7
± 8.0
Timepoint 1 (S7) SI-R: Acquisition Subcategory
Group
Value
95% CI
CREST
14.1
± 5.8
Exposure Therapy
12.9
± 6.1
Timepoint 1 (S7) SI-R: Discarding Subcategory
Group
Value
95% CI
CREST
14.9
± 5.2
Exposure Therapy
15.9
± 5.0
UCSD Performance-Based Skills Assessment (UPSA)Secondary· Baseline to 6 months post-treatment (on average 1 year)
The University of California San Diego (UCSD) Performance-Based Skills Assessment (UPSA)76 is an assessment of everyday functioning skills including household skills (e.g., writing a shopping list based on a recipe, range 0 to 4), communication (e.g., rescheduling appointments, range 0 to 12), finance (e.g., paying a utility bill, range 0 to 11), comprehension and planning (e.g., planning outings, range 0 to 14), and transportation (e.g., comprehension of a bus schedule, range 0 to 9). The subscales are scored, converted to a percentage, and weighed equally toward the total score of 100; highe
Baseline UPSA
Group
Value
95% CI
CREST
49.0
± 7.4
Exposure Therapy
49.1
± 6.8
Baseline UPSA: Financial Subcategory
Group
Value
95% CI
CREST
18.3
± 2.5
Exposure Therapy
18.0
± 2.2
Baseline UPSA: Communication Subcategory
Group
Value
95% CI
CREST
16.2
± 2.6
Exposure Therapy
15.3
± 3.1
Baseline UPSA: Comprehension/Planning Subcategory
Group
Value
95% CI
CREST
14.5
± 5.2
Exposure Therapy
15.8
± 4.2
Baseline UPSA: Transportation Subcategory
Group
Value
95% CI
CREST
16.2
± 2.8
Exposure Therapy
15.9
± 3.8
Baseline UPSA: Household Skills Subcategory
Group
Value
95% CI
CREST
17.6
± 3.7
Exposure Therapy
18.5
± 2.3
Timepoint 1 (S7) UPSA
Group
Value
95% CI
CREST
50.3
± 8.3
Exposure Therapy
50.9
± 6.4
Timepoint 1 (S7) UPSA: Financial Subcategory
Group
Value
95% CI
CREST
18.8
± 1.5
Exposure Therapy
18.3
± 2.3
UCSD SORT TestSecondary· Baseline to 6 months post-treatment
The UCSD SORT Test (U-SORT) is a cognitive test that will be used to measure Veteran participants' organizational skills as they relate to functional capacity. During the administration of the U-SORT, participants are instructed to sort 42 household objects (e.g., bent and unbent paper clips, used and unused condiment packets) from a hypothetical "junk drawer" into either "keep" or "trash" piles. Each item has a correct response and participants are given two minutes to complete the task and one point is awarded for each correctly sorted item, for a total of 42 points (range of 0 to 42). A hig
Baseline USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
33.1
± 3.9
Exposure Therapy
31.2
± 4.7
Timepoint 1 (S7) USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
32.5
± 5.0
Exposure Therapy
32.7
± 5.3
Timepoint 2 (S13) USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
34.2
± 4.1
Exposure Therapy
34.2
± 4.2
Timepoint 3 (S21) USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
33.2
± 6.1
Exposure Therapy
32.9
± 4.4
Post-Treatment USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
34.5
± 3.4
Exposure Therapy
32.3
± 5.2
3 month Post-Treatment USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
36.1
± 4.0
Exposure Therapy
31.4
± 6.9
6 month Post-Treatment USORT
Group
Value
95% CI
Cognitive Rehabilitation and Exposure/Sorting Therapy
35.9
± 2.9
Exposure Therapy
34.0
± 5.2
Specific Levels of Functioning Test (SLOF)Secondary· Baseline to 6 months post-treatment
Self-reported functioning (secondary outcome) will be assessed with the Specific Levels of Functioning test (SLOF)78, a 43-item Likert scale questionnaire with higher scores indicating higher levels of functioning. Subscales include interpersonal relationships (score range of 7 to 35), social acceptability (score range of 6 to 30), participation in activities (score range of 11 to 55), and work skills (score range of 6 to 30). Total of 30 items across four categories and each item ranges from the scale of 1-5 (higher values= better outcomes). Category A. Interpersonal Relationships (items 1-7)
This project will utilize a novel behavioral intervention for hoarding disorder that takes into account age and neurocognitive factors. The goal of this project is to gain knowledge on how treatment components may or may not work for Veterans with hoarding disorder. Further, the investigators hope to increase understanding of functional and long term outcomes in response to hoarding treatment.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 19 September 2024
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