NCT02397486 is a Phase 2 clinical trial of Pentoxifylline in Head and Neck Neoplasms, sponsored by Ain Shams University.

Who is sponsoring NCT02397486?

NCT02397486 is sponsored by Ain Shams University.

What drugs are being tested in NCT02397486?

Interventions in NCT02397486: Pentoxifylline, Vitamin E, Cisplatin, Radiation therapy.

What condition does NCT02397486 study?

NCT02397486 studies Head and Neck Neoplasms.

Is NCT02397486 still recruiting?

NCT02397486 is currently completed. Last updated 26 November 2019.

Last reviewed 2019-11-26 · How we verify

NCT02397486

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients

Completed Phase 2 Last updated 26 November 2019

What this trial tests

Phase 2 trial testing Pentoxifylline in Head and Neck Neoplasms in 60 participants. Completed in 30 June 2018.

Timeline

2 May 2015

Primary endpoint
30 June 2018

30 June 2018

Quick facts

Lead sponsor	Ain Shams University
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	60
Start date	2 May 2015
Primary completion	30 June 2018
Estimated completion	30 June 2018
Sites	1 location across Egypt

Drugs / interventions tested

Pentoxifylline — full drug profile →
Vitamin E (VITAMIN E) — full drug profile →
Cisplatin (cisplatin) — full drug profile →
Radiation therapy — full drug profile →

Conditions studied

Head and Neck Neoplasms — all drugs for Head and Neck Neoplasms →

Sponsor

Ain Shams University

Who can join

18 and older, any sex, with Head and Neck Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine whether pentoxifylline and vitamin E are effective in prevention of radiotherapy- induced toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Radiation-Induced Oral Mucositis.
Maria OM, Eliopoulos N, Muanza T. · · 2017 · cited 253× · PMID 28589080 · DOI 10.3389/fonc.2017.00089
New Frontiers in the Pathobiology and Treatment of Cancer Regimen-Related Mucosal Injury.
Cinausero M, Aprile G, Ermacora P, Basile D, et al · · 2017 · cited 164× · PMID 28642709 · DOI 10.3389/fphar.2017.00354
Antioxidant Therapy in Cancer: Rationale and Progress.
Luo M, Zhou L, Huang Z, Li B, et al · · 2022 · cited 109× · PMID 35740025 · DOI 10.3390/antiox11061128
Oral Mucositis: An Update on Innate Immunity and New Interventional Targets.
Chen C, Zhang Q, Yu W, Chang B, et al · · 2020 · cited 44× · PMID 32479139 · DOI 10.1177/0022034520925421
Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling.
Kirkpatrick DL, Powis G. · · 2017 · cited 38× · PMID 26983373 · DOI 10.1089/ars.2016.6633
Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy.
Petronek MS, Stolwijk JM, Murray SD, Steinbach EJ, et al · · 2021 · cited 29× · PMID 33485837 · DOI 10.1016/j.redox.2021.101864
Pentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: a randomized, controlled study.
Sayed R, El Wakeel L, Saad AS, Kelany M, et al · · 2019 · cited 29× · PMID 31748905 · DOI 10.1007/s12032-019-1334-5
Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects.
Aykin-Burns N, Pathak R, Boerma M, Kim T, et al · · 2019 · cited 11× · PMID 30573184 · DOI 10.1016/j.semradonc.2018.10.008

Verify or expand the search:

Other trials of Pentoxifylline

Trials testing the same drug.

NCT06634056 — Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients U · Phase 2 · not yet recruiting
NCT07349472 — Pentoxifylline in Patients With Ulcerative Colitis · Phase 2 · recruiting
NCT07086794 — Cocaine and Pentoxifylline (BED IN 47) · EARLY_PHASE1 · recruiting
NCT06912763 — Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-contro · Phase 2 · recruiting
NCT07088328 — Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial · NA · not yet recruiting

Other recruiting trials for Head and Neck Neoplasms

Currently open trials in the same condition.

NCT07491536 — Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis · NA · recruiting
NCT06912087 — Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC · Phase 1 · recruiting
NCT06998069 — Head and Neck Cancer Study Project in the Geriatric Population · Phase 3 · recruiting
NCT07158164 — DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment · Phase 4 · recruiting
NCT06303180 — NIDCD Otolaryngology Clinical Protocol Biospecimen Bank · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02397486 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 26 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02397486.

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