Last reviewed · How we verify
NCT02397226
Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery
NA trial testing Radiofrequency ablation in Varicose Veins in 198 participants. Participants enrolled and being followed up; not accepting new ones.
25 November 2021
Quick facts
| Lead sponsor | University Hospital, Linkoeping |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 198 |
| Start date | 1 September 2014 |
| Primary completion | 25 November 2021 |
| Estimated completion | 31 December 2026 |
| Sites | 2 locations across Sweden |
Drugs / interventions tested
- Radiofrequency ablation
- High ligation/stripping
- Radiofrequency ablation catheter
- Tumescent anesthesia
- General anesthesia — full drug profile →
- Vein stripping catheter
Conditions studied
- Varicose Veins — all drugs for Varicose Veins →
- Venous Insufficiency — all drugs for Venous Insufficiency →
Sponsor
University Hospital, Linkoeping
Who can join
Eligibility, any sex, with Varicose Veins or Venous Insufficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
200 patients with insufficient great saphenous veins will be randomized to either radiofrequency ablation or high ligation/stripping (open surgery). They will be examined according to standardized examination protocol Venous Clinical Severity Score (VCSS), with duplex ultrasound and plethysmography pre- and postoperatively (1-month, 1-, 3 and 5 years). They are to fill questionnaires EuroQol 5 Dimensions (EQ-5D) and disease specific Aberdeen Varicose Vein Questionnaire (AVVQ).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact on venous haemodynamics after treatment of great saphenous vein incompetence using plethysmography and duplex ultrasound.
Nelzén POE, Skoog J, Öster M, Zachrisson H. · · 2020 · cited 8× · PMID 31959059 · DOI 10.1177/0268355519898952
Verify or expand the search:
- PubMed search for NCT02397226
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Varicose Veins
Currently open trials in the same condition.
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- NCT05735639 — THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE) · Phase 4 · recruiting
- NCT05410912 — Varicose Vein in Patients Under the Age of 40 · active not recruiting
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Other University Hospital, Linkoeping trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02397226 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Linkoeping
- Last refreshed: 6 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02397226.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing