NCT02377635 (SEASP) is a Phase 1, PHASE2 clinical trial of Anhydrous selenite in Arsenic Poisoning Chronic, sponsored by University of Saskatchewan.

Who is sponsoring NCT02377635?

NCT02377635 is sponsored by University of Saskatchewan.

What drugs are being tested in NCT02377635?

Interventions in NCT02377635: Anhydrous selenite, Sodium chloride.

What condition does NCT02377635 study?

NCT02377635 studies Arsenic Poisoning Chronic.

Is NCT02377635 still recruiting?

NCT02377635 is currently completed. Last updated 30 October 2017.

Last reviewed 2017-10-30 · How we verify

NCT02377635: SEASP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Selenium and Arsenic Pharmacodynamics

Completed Phase 1, PHASE2 Last updated 30 October 2017

What this trial tests

Phase 1, PHASE2 trial testing Anhydrous selenite in Arsenic Poisoning Chronic in 40 participants. Completed in 19 January 2017.

Timeline

10 February 2015

Primary endpoint
19 December 2016

19 January 2017

Quick facts

Lead sponsor	University of Saskatchewan
Phase	Phase 1, PHASE2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	basic science
Enrollment	40
Start date	10 February 2015
Primary completion	19 December 2016
Estimated completion	19 January 2017
Sites	1 location across Bangladesh

Drugs / interventions tested

Anhydrous selenite
Sodium chloride (Sodium Chloride) — full drug profile →

Conditions studied

Arsenic Poisoning Chronic — all drugs for Arsenic Poisoning Chronic →

Sponsor

University of Saskatchewan

Who can join

Adults 18 to 65, male only, with Arsenic Poisoning Chronic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This clinical trial should prove that selenium can treat arsenic exposure in humans by promoting excretion. The new trial differs from previous trials in that participants will be maintained in a local clinic and provided with food and water from their home villages. The purpose of this study to determine the fate of selenium supplements in feces, urine and blood of volunteers living in conditions of high arsenic load in drinking water. The use of a clinic will enable monitoring of all intake and excretion of both arsenic and selenium, and will ensure that participants take their selenium doses or placebo as appropriate. This proof of concept is absolutely essential groundwork for any remediation strategy involving selenium supplements.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Megaphages infect Prevotella and variants are widespread in gut microbiomes.
Devoto AE, Santini JM, Olm MR, Anantharaman K, et al · · 2019 · cited 172× · PMID 30692672 · DOI 10.1038/s41564-018-0338-9
Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria.
Matheus Carnevali PB, Schulz F, Castelle CJ, Kantor RS, et al · · 2019 · cited 61× · PMID 30692531 · DOI 10.1038/s41467-018-08246-y

Verify or expand the search:

Other University of Saskatchewan trials

Trials by the same sponsor.

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NCT03401294 — Conversion From Unresectable To Resectable Metastatic Colorectal Cancer. · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02377635 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Saskatchewan
Last refreshed: 30 October 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02377635.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing