Last reviewed · How we verify

Sodium Chloride 23.4% (Sodium Chloride)

Pfizer Inc. · FDA-approved approved Small molecule Quality 64/100

Exerts mechanical cleansing action for sterile irrigation of body cavities, tissues, wounds, and surgical equipment.

Sodium Chloride 0.9% Irrigation, USP is a sterile, nonpyrogenic electrolyte solution indicated for general irrigation, washing, rinsing, and dilution purposes including blood cell washing. The solution is isotonic and considered generally compatible with living tissues and organs. It is contraindicated for injection by usual parenteral routes and should not be used during electrosurgical procedures. The product serves as a mechanical cleansing agent and vehicle for drugs used in irrigation and pharmaceutical preparations.

At a glance

Generic nameSodium Chloride
SponsorPfizer Inc.
Drug classElectrolyte irrigation solution
TargetNot specified
ModalitySmall molecule
PhaseFDA-approved

Mechanism of action

Sodium Chloride 0.9% Irrigation, USP provides mechanical cleansing action for irrigation purposes. Sodium chloride dissociates in water to provide sodium (Na+) and chloride (Cl−) ions. Sodium is the principal cation of extracellular fluid and plays a large part in therapy of fluid and electrolyte disturbances, while chloride has an integral role in buffering action during oxygen and carbon dioxide exchange in red blood cells. The distribution and excretion of sodium and chloride are largely controlled by the kidney, which maintains balance between intake and output. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight, with water balance maintained by various regulatory mechanisms and sodium playing a major role in maintaining physiologic equilibrium.

Approved indications

Common side effects