NCT02360137 (ANTIQUE) is a clinical trial in Carotid Artery Plaque, sponsored by University Hospital Ostrava.

Who is sponsoring NCT02360137?

NCT02360137 is sponsored by University Hospital Ostrava.

What condition does NCT02360137 study?

NCT02360137 studies Carotid Artery Plaque.

Is NCT02360137 still recruiting?

NCT02360137 is currently active, enrolled. Last updated 28 July 2023.

Last reviewed 2023-07-28 · How we verify

NCT02360137: ANTIQUE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Atherosclerotic Plaque Characteristics Associated With a Progression Rate of the Plaque in Carotids and a Risk of Stroke

Active, enrolled Last updated 28 July 2023

What this trial tests

trial in Carotid Artery Plaque in 1,863 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 April 2015

Primary endpoint
1 January 2026

1 June 2026

Quick facts

Lead sponsor	University Hospital Ostrava
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	1,863
Start date	1 April 2015
Primary completion	1 January 2026
Estimated completion	1 June 2026
Sites	1 location across Czechia

Conditions studied

Carotid Artery Plaque — all drugs for Carotid Artery Plaque →

Sponsor

University Hospital Ostrava

Who can join

Adults 30 to 90, any sex, with Carotid Artery Plaque. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Atherosclerosis is the most common cause of stroke. The aims of the project are to compare the visual and digital analysis of sonographic images of atherosclerotic plaque in carotids in vivo, in vitro and with a histological composition of the plaque obtained from patients indicated to carotid endarterectomy, to compare the characteristics of symptomatic and asymptomatic atherosclerotic plaques and, subsequently to verify a hypothesis that ultrasound can identify the sonographic plaque characteristics associated with an increased risk of plaque progression and of ischemic stroke (unstable plaque) in patients with carotid atherosclerosis. Identifying of the sonographic characteristics of unstable plaque will allow to improve indication criteria for carotid endarterectomy or stenting and also potential changing of a drug therapy in patients with unstable plaque in the future. Cost efficiency and availability of duplex ultrasound equipment may enable to improve diagnosis of unstable plaque using this new plaque characteristics evaluation in the majority of patients with carotid plaques.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Risk factors for carotid plaque progression after optimising the risk factor treatment: substudy results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the carotid Bifurcation Plaque Study (ANTI
Školoudík D, Kešnerová P, Hrbáč T, Netuka D, et al · · 2022 · cited 7× · PMID 34853082 · DOI 10.1136/svn-2021-001068
Peak systolic velocity ratio for evaluation of internal carotid artery stenosis correlated with plaque morphology: substudy results of the ANTIQUE study.
Pakizer D, Vybíralová A, Jonszta T, Roubec M, et al · · 2023 · cited 6× · PMID 38020621 · DOI 10.3389/fneur.2023.1206483
Factors influencing quality of life in patients followed in the neurosonology laboratory for carotid stenosis.
Fadrná T, Mikšová Z, Herzig R, Langová K, et al · · 2018 · cited 1× · PMID 29703211 · DOI 10.1186/s12955-018-0902-2
Extracranial carotid plaque calcification and its association with risk factors for cerebrovascular events: insights from the ANTIQUE study.
Pakizer D, Šalounová D, Školoudík D. · · 2025 · PMID 39944551 · DOI 10.3389/fneur.2025.1532883

Verify or expand the search:

Other recruiting trials for Carotid Artery Plaque

Currently open trials in the same condition.

NCT07296965 — Oral Microbiome in Carotid Atherosclerosis · recruiting
NCT07004673 — 18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque P · recruiting
NCT05975554 — The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution. · NA · active not recruiting
NCT04073797 — PET Imaging of Inflammation and Lipid Lowering Study · NA · recruiting

Other University Hospital Ostrava trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02360137 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Ostrava
Last refreshed: 28 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02360137.

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