Who is sponsoring NCT02334644?

NCT02334644 is sponsored by McMaster University.

What condition does NCT02334644 study?

NCT02334644 studies Obsessive-Compulsive Disorder.

Is NCT02334644 still recruiting?

NCT02334644 is currently terminated. Last updated 10 September 2021.

Last reviewed 2021-09-10 · How we verify

NCT02334644

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Probiotic Treatment in Adult Obsessive-Compulsive Disorder

Terminated Phase 4 Last updated 10 September 2021

What this trial tests

Phase 4 trial testing Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in Obsessive-Compulsive Disorder in 15 participants. Terminated before completion.

Timeline

1 September 2018

Primary endpoint
30 April 2021

30 April 2021

Quick facts

Lead sponsor	McMaster University
Phase	Phase 4
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	15
Start date	1 September 2018
Primary completion	30 April 2021
Estimated completion	30 April 2021
Sites	1 location across Canada

Drugs / interventions tested

Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)
Placebo

Conditions studied

Obsessive-Compulsive Disorder — all drugs for Obsessive-Compulsive Disorder →

Sponsor

McMaster University

Who can join

Adults 18 to 65, any sex, with Obsessive-Compulsive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will evaluate the effectiveness of 12-weeks of probiotic treatment in adults with primary Obsessive-Compulsive Disorder and whether this treatment will alter the microbiota composition in these patients.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Obsessive-compulsive disorder.
Stein DJ, Costa DLC, Lochner C, Miguel EC, et al · · 2019 · cited 495× · PMID 31371720 · DOI 10.1038/s41572-019-0102-3
What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders?
Martino D, Johnson I, Leckman JF. · · 2020 · cited 37× · PMID 33041996 · DOI 10.3389/fneur.2020.567407
Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study.
Westwell-Roper C, Williams KA, Samuels J, Bienvenu OJ, et al · · 2019 · cited 28× · PMID 31170001 · DOI 10.1089/cap.2018.0140
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives.
Dhiman A, Mehan S, Khan Z, Tiwari A, et al · · 2025 · cited 4× · PMID 39219434 · DOI 10.2174/0115665232316708240828063527

Verify or expand the search:

Other recruiting trials for Obsessive-Compulsive Disorder

Currently open trials in the same condition.

NCT06575075 — Pilot Study of RR-HNK in OCD · Phase 1, PHASE2 · recruiting
NCT05783817 — MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study) · Phase 2 · recruiting
NCT07065669 — Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation · NA · recruiting
NCT06376734 — Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness · Phase 2 · recruiting
NCT07000812 — EEG Evaluation of CBT for Obsessive-Compulsive Disorder · NA · active not recruiting

Other McMaster University trials

Trials by the same sponsor.

NCT06231069 — Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults · NA · withdrawn
NCT07213492 — Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder · NA · recruiting
NCT07486505 — Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, M · NA · not yet recruiting
NCT07408128 — Partner4Exercise Randomized Controlled Trial · Phase 2, PHASE3 · not yet recruiting
NCT07459777 — Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anteri · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02334644 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by McMaster University
Last refreshed: 10 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02334644.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing