NCT02248519: LOGICA

Laparoscopic Versus Open Gastrectomy for Gastric Cancer

Completed NA Last updated 19 February 2026

What this trial tests

NA trial testing Open Gastrectomy in Gastric Cancer in 210 participants. Completed in 1 December 2023.

Timeline

1 December 2014

Primary endpoint
1 November 2018

1 December 2023

Quick facts

Lead sponsor	UMC Utrecht
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	210
Start date	1 December 2014
Primary completion	1 November 2018
Estimated completion	1 December 2023
Sites	10 locations across Netherlands

Drugs / interventions tested

• Open Gastrectomy
• Laparoscopic Gastrectomy

Conditions studied

• Gastric Cancer — all drugs for Gastric Cancer →

Sponsor

UMC Utrecht — full company profile →

Who can join

18 and older, any sex, with Gastric Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is the first randomized controlled trial comparing laparoscopic and open gastrectomy for resectable gastric cancer in a Western population. The hypothesis is that laparoscopic gastrectomy will result in a lower post-operative burden by means of shorter post-operative hospital stay. Secondarily that laparoscopic gastrectomy is hypothesized to be associated with lower post-operative morbidity and readmissions, higher cost-effectiveness, and better post-operative quality of life, with similar mortality and oncologic outcomes, compared to open gastrectomy. The study starts on 1 December 2014. Inclusion and follow-up will take three and five years respectively. Short-term results will be analyzed and published after discharge of the last randomized patient.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial).
   Haverkamp L, Brenkman HJ, Seesing MF, Gisbertz SS, et al · · 2015 · cited 67× · PMID 26219670 · DOI 10.1186/s12885-015-1551-z
2. Pattern of lymph node metastases in gastric cancer: a side-study of the multicenter LOGICA-trial.
   de Jongh C, Triemstra L, van der Veen A, Brosens LAA, et al · · 2022 · cited 23× · PMID 36103060 · DOI 10.1007/s10120-022-01329-2
3. Distal Versus Total D2-Gastrectomy for Gastric Cancer: a Secondary Analysis of Surgical and Oncological Outcomes Including Quality of Life in the Multicenter Randomized LOGICA-Trial.
   de Jongh C, van der Veen A, Brosens LAA, Nieuwenhuijzen GAP, et al · · 2023 · cited 13× · PMID 37340107 · DOI 10.1007/s11605-023-05683-z
4. Laparoscopic Surgery for Gastric Cancer: The European Point of View.
   Chevallay M, Jung M, Berlth F, Seung-Hun C, et al · · 2019 · cited 13× · PMID 31214260 · DOI 10.1155/2019/8738502
5. Cost-effectiveness of Laparoscopic vs Open Gastrectomy for Gastric Cancer: An Economic Evaluation Alongside a Randomized Clinical Trial.
   van der Veen A, van der Meulen MP, Seesing MFJ, Brenkman HJF, et al · · 2023 · cited 10× · PMID 36576822 · DOI 10.1001/jamasurg.2022.6337
6. Compliance to D2 lymphadenectomy in laparoscopic gastrectomy.
   Eshuis WJ, van Berge Henegouwen MI, Draaisma WA, Gisbertz SS. · · 2018 · cited 8× · PMID 29926307 · DOI 10.1007/s13304-018-0553-1
7. Minimally invasive surgery in advanced gastric cancer.
   Lee S, Kim HH. · · 2022 · cited 7× · PMID 35634188 · DOI 10.1002/ags3.12559
8. Pain and Opioid Consumption After Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Secondary Analysis of a Multicenter Randomized Clinical Trial (LOGICA-Trial).
   van der Veen A, Ramaekers M, Marsman M, Brenkman HJF, et al · · 2023 · cited 4× · PMID 37464143 · DOI 10.1007/s11605-023-05728-3