Last reviewed · How we verify
NCT02241603: IRRSO
Insulin Resistance and Reward
Phase 2 trial testing Weight loss in Obesity in 59 participants. Completed in 1 July 2020.
1 July 2020
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 59 |
| Start date | 17 November 2014 |
| Primary completion | 1 July 2020 |
| Estimated completion | 1 July 2020 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Weight loss — full drug profile →
Conditions studied
- Obesity — all drugs for Obesity →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
Adults 25 to 60, any sex, with Obesity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obesity is a common problem in the Veteran population as at least 1 in 3 Veterans are obese. When obese people eat food they have less response in areas of the brain that sense pleasure (reward). Decreased pleasure response to food predicts future weight gain. It is not known if this poor brain response is reversible or why obese people's brains respond this way. Insulin in the brain regulates the brain's sensing of pleasure. As people gain weight the function of insulin becomes impaired. The investigators will study if impaired function of insulin is related to a poor brain response to food and if this brain response predicts voluntary intake of food and response to a diet. The investigators will also study if improving the function of insulin with weight loss improves the brain response. These studies will improve the understanding as to why weight loss is difficult and inform us if improving insulin signaling is a potential way to treat obesity.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Dorsal striatal response to taste is modified by obesity and insulin resistance.
Dunn JP, Lamichhane B, Smith GI, Garner A, et al · · 2023 · cited 3× · PMID 37475685 · DOI 10.1002/oby.23799
Verify or expand the search:
- PubMed search for NCT02241603
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for Obesity
Currently open trials in the same condition.
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Other VA Office of Research and Development trials
Trials by the same sponsor.
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- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02241603 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 8 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02241603.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing