Last reviewed · How we verify

NCT02210065

Autologous Cytomegalovirus (CMV)-Specific Cytotoxic T Cells for Cytomegalovirus (CMV) Reactivation

Completed Phase 2 Results posted Last updated 17 March 2020
What this trial tests

Phase 2 trial testing Cytomegalovirus (CMV)-Specific Cytotoxic T Cells (CTLs) in Leukemia in 6 participants. Completed in 13 May 2019.

Timeline
3 March 2015
Primary endpoint
13 May 2019
13 May 2019

Quick facts

Lead sponsorM.D. Anderson Cancer Center
PhasePhase 2
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment6
Start date3 March 2015
Primary completion13 May 2019
Estimated completion13 May 2019
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

M.D. Anderson Cancer Center — full company profile →

Who can join

18 and older, any sex, with Leukemia or Lymphoma. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants With Non-Relapse Mortality Primary · 6 months

Non-relapse mortality defined as death because of causes other than relapse of the underlying hematological malignancy.

GroupValue95% CI
Cytomegalovirus (CMV)-Specific Cytotoxic T Cells (CTLs)0
Success Rate of Cytotoxic T Cells Primary · 28 days

Treatment considered a success if the patient does not require initiation of cytomegalovirus (CMV) anti-viral therapy.

GroupValue95% CI
Cytomegalovirus (CMV)-Specific Cytotoxic T Cells (CTLs)1

Sponsor's own description

The goal of this clinical research study is to learn if giving cytotoxic T lymphocytes (CTLs) can help control CMV when it reactivates (becomes active again) in patients who receive an allogeneic stem cell transplant. Researchers also want to learn about the safety of giving CTLs to patients who have had a stem cell transplant.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Trial Watch: Adoptive cell transfer for oncological indications.
    Aranda F, Buqué A, Bloy N, Castoldi F, et al · · 2015 · cited 28× · PMID 26451319 · DOI 10.1080/2162402x.2015.1046673
  2. CMV Prevention and Treatment in Transplantation: What's New in 2019.
    Stern A, Papanicolaou GA. · · 2019 · cited 23× · PMID 31732823 · DOI 10.1007/s11908-019-0699-0

Verify or expand the search:

Other recruiting trials for Leukemia

Currently open trials in the same condition.

Other M.D. Anderson Cancer Center trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02210065.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing