Last reviewed · How we verify
NCT02199483
Metabolic and Neural Adaptations to Weight Loss, Plateau, and Regain
trial in Healthy Volunteers. Withdrawn.
29 June 2017
Quick facts
| Lead sponsor | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
|---|---|
| Status | Withdrawn |
| Study type | OBSERVATIONAL |
| Start date | 21 July 2014 |
| Primary completion | 29 June 2017 |
| Estimated completion | 29 June 2017 |
Conditions studied
- Healthy Volunteers — all drugs for Healthy Volunteers →
Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Who can join
Adults 18 to 55, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: \- Many people can lose weight by changing their diet or exercise. However, most people eventually regain the weight over time. This weight regain may be related to changes in metabolism as well as changes in the brain caused by weight loss. Researchers want to learn more about these changes. Objective: \- To see how weight loss and regain affects the body s metabolism and the brain of obese but healthy adults. Eligibility: \- Obese but healthy adults age 18-55 who plan to participate in a weight loss program at one of several participating clinics or resorts. Design: * Participants will first be screened at home through questionnaires and telephone interviews. * Participants will then be screened at the NIH with blood tests, medical history, physical exam, electrocardiograms, and questionnaires. They will have a mock magnetic resonance imaging (MRI) scan. * At visit 1, participants will stay at the NIH and will: * have MRI and PET brain scans. * have body composition scans and measurements. * give blood samples. * eat a special diet. * wear a physical activity monitor. * provide a urine sample and body weight daily. * drink a special type of water to measure calorie burn. * wear a clear plastic hood over their head while lying down, to collect exhaled air. * spend 24 hours in a room that measures oxygen and carbon dioxide. * complete questionnaires and computer tasks. * After visit 1, participants will give daily urine samples and weight and physical activity measurements from home. Then they will follow a lifestyle intervention for weight loss and give daily weight and activity measurements. * Visits 2, 3, and 4 occur 1-26 months after the start of the weight loss program. Participants will repeat procedures from visit 1. Visits 1-4 last 4 days each. * Researchers will track participants weight and physical activity for up to 26 months after visit 2.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT02199483
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02199483 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Last refreshed: 12 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02199483.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing