NCT02167906

Impact of Hand Osteoarthritis on Arterial Stiffness

Completed NA Last updated 14 December 2022

What this trial tests

NA trial testing arterial stiffness measurement in Osteoarthritis in 80 participants. Completed in 16 October 2019.

Timeline

1 September 2014

Primary endpoint
16 October 2019

16 October 2019

Quick facts

Lead sponsor	University Hospital, Montpellier
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	screening
Enrollment	80
Start date	1 September 2014
Primary completion	16 October 2019
Estimated completion	16 October 2019
Sites	1 location across France

Drugs / interventions tested

• arterial stiffness measurement

Conditions studied

• Osteoarthritis — all drugs for Osteoarthritis →

Sponsor

University Hospital, Montpellier

Who can join

Adults 45 to 65, any sex, with Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients affected by osteoarthritis (OA) have an increase overall mortality compared to the general population, mainly due to cardiovascular diseases. OA patients without cardiovascular risk have a 10 years cardiovascular events higher of around 15-30 %. Although the molecular mechanisms are still not well known, the structure and function of the vessel wall can be affected by several inflammatory and metabolic parameters during OA.These functional and structural changes of the arterial wall leads to arterial stiffness, measured by the pulse-wave velocity (PWV). PWV is the most widely used technique to assess arterial stiffness and has been shown to have predictive value for morbidity and mortality. In our study, we planned to compare arterial stiffness in OA patients with healthy subjects.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.